A two-gene blood test for methylated DNA sensitive for colorectal cancer

SK Pedersen, RT Baker, A McEvoy, DH Murray… - PloS one, 2015 - journals.plos.org
… LCL, RTB, SKP, PLM, SM, TL are inventors on one or more patent applications covering
the methylation DNA biomarkers described in this paper. This does not alter the authors' …

DNA methylation biomarkers for blood-based colorectal cancer screening

C Lofton-Day, F Model, T DeVos, R Tetzner… - Clinical …, 2008 - academic.oup.com
… concentration to 10 ng/PCR reaction for subsequent testing. Calibration curves were …
Universal Methylated DNA concentrations between 400 μg/L and 5 mg/L. We tested 10 ng DNA per …

Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer

JD Warren, W Xiong, AM Bunker, CP Vaughn… - BMC medicine, 2011 - Springer
… an improved SEPT9 blood-based CRC screening test with a … SEPT9 methylated DNA, we
demonstrate that the new test has … test is demonstrated to specifically identify CRCs from blood

DNA methylation as a promising landscape: A simple blood test for breast cancer prediction

G Khakpour, A Pooladi, P Izadi, M Noruzinia… - Tumor Biology, 2015 - Springer
… In the case of identifying epimarker in the peripheral blood shown in Table 1, we have two
alternatives: methylation in DNA of circulating tumor cell and WBC. Since cell-free DNA of …

Global methylation profiles in DNA from different blood cell types

HC Wu, L Delgado-Cruzata, JD Flom, M Kappil… - Epigenetics, 2011 - Taylor & Francis
… of differential methylation patterns in different blood cell … MN DNA methylation correlates so
closely with WBC methylation. … in the blood (70%), would be more correlated with WBC DNA

From Discovery to the Clinic: The Novel DNA Methylation Biomarker mSEPT9 For The Detection of Colorectal Cancer in Blood

SR Payne - Epigenomics, 2010 - Taylor & Francis
… occult blood tests (… blood-based test would increase compliance with the current colorectal
cancer screening guidelines. In addition, a blood-based test would remove the burden of test

DNA methylation profiling for a confirmatory test for blood, saliva, semen, vaginal fluid and menstrual blood

HY Lee, SE Jung, EH Lee, WI Yang, KJ Shin - Forensic Science …, 2016 - Elsevier
DNA methylation at the 2 CpG markers was further tested by targeted bisulfite sequencing
of 461 additional samples including 49 blood, … the menstrual blood test in forensic casework. …

Blood-based DNA methylation as biomarker for breast cancer: a systematic review

Q Tang, J Cheng, X Cao, H Surowy, B Burwinkel - Clinical epigenetics, 2016 - Springer
… of using blood-based DNA methylation marker as promising marker for BC risk stratification,
as several studies found associations between certain methylation level in blood and BC risk…

[HTML][HTML] Blood free-circulating DNA testing by highly sensitive methylation assay to diagnose colorectal neoplasias

Y Suehiro, S Hashimoto, S Higaki, I Fujii, C Suzuki… - Oncotarget, 2018 - ncbi.nlm.nih.gov
… sample amount without DNA bisulfite treatment. We performed this study to … DNA testing by
the new methylation assay in combination with and without the fecal immunochemical test for …

Free-circulating methylated DNA in blood for diagnosis, staging, prognosis, and monitoring of head and neck squamous cell carcinoma patients: an observational …

A Schröck, A Leisse, L de Vos, H Gevensleben… - Clinical …, 2017 - academic.oup.com
… result, 92% (24/26) suffered from a disease progression or a second cancer and/or died
within 1 year after the first positive blood test, which is in line with the specificity of the test. …