… on mammalian organisms, where epigenetic DNA methylation targets … Citation 3 Mice
lacking the DNA methylating enzymes … that DNA methylation is essential in mammals.Citation 4 …

… methylation-dependent transcription factor–DNA interactions are important stepping stones
towards a mechanistic understanding of methylation-… with methylated CpG sites in mammals, …

… These methylation and expression … DNA methylation's effects on transcription can be subtle,
but important. Furthermore, they show that binding of one transcription factor can cause DNA …

… of transcription factor binding over DNA methylation in this … unmethylated state, even
without measurable transcription … of transcription factor binding and DNA methylation confirms …

… Thus, even though there is clear evidence that the binding of transcription factors such as
myc to their cognate sites can be blocked by methylation (39), detailed experiments on the …

… effect of cytosine methylation on transcription factor binding, we … transcription factors and
extended DNA binding domains to … in mammalian genomes are methylated, but the methylation …

… of transcription factors leads to a loss of methylation when the gene is activated (12–17).
Under this model, changes in methylation density are a result of transcriptional activation rather …

… unmethylated and in an open chromatin conformation could facilitate the ability of transcription
factors … of the Sp1 transcription factor provided a physical block to methylation spreading. …

… binding for methylated or unmethylated DNA, motifs with CpGs in the center were not bound
when methylated and motifs with CpGs in the flank were bound when methylated [45]. This …

… , LMRs are occupied by transcription factors and their binding is both necessary and
sufficient to generate LMRs, indicating transcription factors can influence local DNA methylation. …