Advances in epigenetic research of adolescent idiopathic scoliosis and congenital scoliosis
D Sun, Z Ding, Y Hai, Y Cheng - Frontiers in Genetics, 2023 - frontiersin.org
… scoliosis groups, thereby suggesting that DNA methylation status had strong potential for
use as a novel biomarker to determine prognosis. This locus is close to the gene encoding …
use as a novel biomarker to determine prognosis. This locus is close to the gene encoding …
Whole-genome methylation analysis reveals novel epigenetic perturbations of congenital scoliosis
… Congenital scoliosis (CS) is a congenital disease caused by malformations of vertebrae. …
methylation may be associated with the formation of hemivertebra and congenital scoliosis. …
methylation may be associated with the formation of hemivertebra and congenital scoliosis. …
Abnormal TNS3 gene methylation in patients with congenital scoliosis
YT Wu, H Zhang, M Tang, C Guo, S Liu, J Li… - BMC Musculoskeletal …, 2022 - Springer
… In this article, we explore promoter region methylation in CS and clarify whether DNA
methylation plays a role in the pathogenesis of CS to possibly provide a new explanation for its …
methylation plays a role in the pathogenesis of CS to possibly provide a new explanation for its …
High methylation of lysine acetyltransferase 6B is associated with the Cobb angle in patients with congenital scoliosis
Y Wu, H Zhang, M Tang, C Guo, A Deng, J Li… - Journal of Translational …, 2020 - Springer
… In this study, methylation analysis of peripheral blood genomes of patients with CS revealed
… , and the methylation level was positively correlated with the Cobb angle. DNA methylation …
… , and the methylation level was positively correlated with the Cobb angle. DNA methylation …
A twin‑pair analysis indicates congenital scoliosis is associated with allele‑specific methylation in the SVIL gene
Z Zhang, Y Chen, Y Wu, Y Hao… - Molecular …, 2020 - spandidos-publications.com
… Congenital scoliosis (CS) is a congenital disease resulting in … ) and epigenetic (by methylated
DNA immunoprecipitation … polymorphisms and in methylation patterns between the twins …
DNA immunoprecipitation … polymorphisms and in methylation patterns between the twins …
Severity of idiopathic scoliosis is associated with differential methylation: An epigenome-wide association study of monozygotic twins with idiopathic scoliosis
PM Carry, EA Terhune, GD Trahan, LA Vanderlinden… - Genes, 2021 - mdpi.com
… Genome-wide methylation in blood was measured with the Infinium … in methylation and
methylation variability between discordant twins and tested the association between methylation …
methylation variability between discordant twins and tested the association between methylation …
Value of DNA methylation in predicting curve progression in patients with adolescent idiopathic scoliosis
Y Meng, T Lin, S Liang, R Gao, H Jiang, W Shao… - …, 2018 - thelancet.com
… We performed the first analysis of DNA methylation differences for the etiology of AIS curve
severity using a genome-wide approach and found evidence suggesting a lack of differences …
severity using a genome-wide approach and found evidence suggesting a lack of differences …
Integrated DNA methylation analysis reveals a potential role for PTPRN2 in Marfan syndrome scoliosis
Z Zheng, J Xu, J Chen, B Jiang, H Ma, L Li, Y Li… - JOR …, 2024 - Wiley Online Library
… The CSMD1 gene variants (rs11136775 and rs13260434) have shown associations with
congenital scoliosis, 67 and rs11787412 has been linked to adolescent idiopathic …
congenital scoliosis, 67 and rs11787412 has been linked to adolescent idiopathic …
Abnormal PITX1 gene methylation in adolescent idiopathic scoliosis: a pilot study
B Shi, L Xu, S Mao, L Xu, Z Liu, X Sun, Z Zhu… - BMC Musculoskeletal …, 2018 - Springer
… of methylation of all 6 CpG sites were automatically analyzed by the PyroMark® Q24 software.
The exact frequency of methylation … between methylated and unmethylated samples [19]. …
The exact frequency of methylation … between methylated and unmethylated samples [19]. …
Whole-genome methylation analysis of phenotype discordant monozygotic twins reveals novel epigenetic perturbation contributing to the pathogenesis of adolescent …
… We also found the DMR associated genes were significantly overlapped with scoliosis
related genes, which indicated that the methylation of scoliosis-related genes may play a pivotal …
related genes, which indicated that the methylation of scoliosis-related genes may play a pivotal …
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