[HTML][HTML] microRNA-146a modulates behavioural activity, neuroinflammation, and oxidative stress in adult mice
Small non-coding miRNA act as key regulators of several physiological processes due to
their ability to interact with numerous target mRNA within a network. Whilst several miRNA
can act in concert to regulate target mRNA expression, miR-146a has emerged as a critical
modulator of inflammation by targeting key upstream signalling proteins of the nuclear factor
kappa-light-chain-enhancer of activated B cells (NF-κB) pathway and reductions in this
miRNA have been observed in several neurological and neurodegenerative disorders …
their ability to interact with numerous target mRNA within a network. Whilst several miRNA
can act in concert to regulate target mRNA expression, miR-146a has emerged as a critical
modulator of inflammation by targeting key upstream signalling proteins of the nuclear factor
kappa-light-chain-enhancer of activated B cells (NF-κB) pathway and reductions in this
miRNA have been observed in several neurological and neurodegenerative disorders …
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