… Direct association of BRAF mutation with the clinical … The BRAF mutation has even
been correlated with PTC … Some molecular mechanisms determining BRAF mutation-promoted …

… to analyze BRAF mutation status in formalin-fixed paraffin-embedded tumor samples. The
cobas Mutation Test has been designed specifically to detect BRAF V600E mutations, and the …

… BRAF mutation, namely a 1795GTT insertion, resulting in BRAF V599Ins , and describe its
biochemical and molecular … of the molecular basis responsible for the activation of BRAF …

… BRAF pathway has become a target of interest for molecular therapy, with promising results
emerging from clinical trials. Here, the role of the most common BRAF mutation BRAF … -base …

… a single base substitution to glutamic acid, yet mutations at this … These data suggest that
BRAF V599 mutations uncouple … BRAF V599 mutants can be even further activated by mutant …

… , with its 3 end complementary to the base immediately 3 to the nucleotide of interest. Primer
extension with labeled nucleotides can then proceed if a mutated base is present or absent, …

… V600E) mutation. However, a subset of melanomas harbor non-p.V600E BRAF mutations, …
To better understand the BRAF mutation profile in melanomas, we retrospectively analyzed …

… BRAF gene and other members of RAS/RAF cascade in human cancers and RAS/MAPK
syndromes, and focuses the molecular basis and clinical genetics of BRAF … no BRAF mutations …

… Targeted therapy with BRAF and MEK inhibitors is associated with significant long-term …
patients with BRAF V600-mutated melanoma. Therefore, molecular testing for BRAF mutations is …

… of mutated BRAF in the development and progression of melanoma as the basis for
understanding the mechanism of action of BRAF … development of small molecule BRAF inhibitors. …