… Here, we provide an overview of the “molecular glue” concept, … clinical and preclinical
molecular glue degraders, and discuss … , molecular glue degraders can induce the degradation of …

… in ubiquitination and subsequent degradation of the recruited … already work as molecular
glue degraders, with many more … by monovalent degraders, with a focus on molecular glues …

… be liganded via small organic molecules. Conversely, molecular glue degraders were shown
to … thalidomide analogs (IMiDs) as molecular glue degraders exemplify how this particular …

… Targeted protein degradation with molecular glue degraders … through proteasome-mediated
degradation. However, we … -targeting ligands into molecular glue degraders. To overcome …

… degradation of the target. Proteolysis-targeting chimeras (PROTACs) and molecular glue
(MG) degraders are two major classes of protein degraders (Figure 1a). PROTACs are bivalent …

… To identify candidate drug resistance mechanisms to molecular glue degraders, we … treated
with either vehicle or the appropriate molecular glue degraders to select for candidate drug …

Molecular glue degraders (MGDs) are small molecules that degrade proteins of interest via
the ubiquitin–proteasome system. While MGDs were historically discovered serendipitously, …

… Of particular interest are molecular glue degraders, which … discoveries of other molecular
glue degraders 7,8,9,10,11,12,… (CDK) inhibitor, is a molecular glue degrader that binds CDK12–…

… molecular glues have exceptional promise as a therapeutic modality. (1) Thus far, molecular
glue degraders … molecular glues can be utilized to induce the degradation of neosubstrates. …

… a PROTAC MDM2 degrader but instead works as a molecular glue, inducing degradation of
a … can convert a bona fide PROTAC degrader into a molecular glue compound, which has a …