DNA adductomics
… adductomics approach is required that can simultaneously screen for multiple DNA adducts
derived from known and unknown exposures and from biological responses to exposures …
derived from known and unknown exposures and from biological responses to exposures …
DNA adducts: mass spectrometry methods and future prospects
… Some N7-alkylguanines (which are for many alkylating agents the most abundant DNA adduct…
, in which the adduct is detected by multiple reaction monitoring of the fragmentation MH + …
, in which the adduct is detected by multiple reaction monitoring of the fragmentation MH + …
Simultaneous detection of multiple DNA adducts in human lung samples by isotope-dilution UPLC-MS/MS
BH Monien, F Schumacher, K Herrmann… - Analytical …, 2015 - ACS Publications
… differed markedly suiting our goal to develop a versatile method for the quantification of
multiple DNA adducts that may be easily extended to the quantification of other adducts in the …
multiple DNA adducts that may be easily extended to the quantification of other adducts in the …
Quantification of multiple DNA adducts formed through oxidative stress using liquid chromatography and electrospray tandem mass spectrometry
MI Churchwell, FA Beland… - Chemical Research in …, 2002 - ACS Publications
… for the formation of etheno-DNA adducts through reaction of DNA bases with epoxy derivatives
of α,β-… Figure 1 Structures of target oxidative DNA adducts and sites of labeling in internal …
of α,β-… Figure 1 Structures of target oxidative DNA adducts and sites of labeling in internal …
Multiple DNA adducts in lymphocytes of smokers and nonsmokers determined by 32P- postlabeling analysis
GD Jahnke, CL Thompson, MP Walker… - …, 1990 - academic.oup.com
… In this study, multiple DNA adducts were detected in human lymphocytes with the PI nuclease
modification of the 32Ppostlabeling method. For the subjects sampled, the pattern of these …
modification of the 32Ppostlabeling method. For the subjects sampled, the pattern of these …
Comparison of multiple DNA adduct types in tumor adjacent human lung tissue: effect of cigarette smoking
… total aromatic–DNA adducts and putative BPDE–DNA adducts were found to be higher in
smokers than in non-smokers by 32 P-postlabeling. In other studies on PAH–DNA adducts in …
smokers than in non-smokers by 32 P-postlabeling. In other studies on PAH–DNA adducts in …
Quantitation of DNA adducts by stable isotope dilution mass spectrometry
N Tretyakova, M Goggin, D Sangaraju… - Chemical research in …, 2012 - ACS Publications
… While multiple experimental methodologies have been developed for DNA adduct
analysis in … As typical DNA adduct concentrations in biological samples are between 0.01–10 …
analysis in … As typical DNA adduct concentrations in biological samples are between 0.01–10 …
Mass spectrometry for the assessment of the occurrence and biological consequences of DNA adducts
… of DNA adducts. In this review, we summarized the development of MS techniques on these
fronts for DNA adduct … multiple DNA adducts derived from different genotoxic agents in …
fronts for DNA adduct … multiple DNA adducts derived from different genotoxic agents in …
DNA adducts: Formation, biological effects, and new biospecimens for mass spectrometric measurements in humans
B Hwa Yun, J Guo, M Bellamri… - Mass spectrometry …, 2020 - Wiley Online Library
… The simultaneous measurement of multiple DNA adducts, or DNA adductomics, by different
MS scanning approaches, has recently been reviewed.225, 226 Due to the complexity of the …
MS scanning approaches, has recently been reviewed.225, 226 Due to the complexity of the …
Endogenous DNA adducts: potential and paradox
LJ Marnett, PC Burcham - Chemical research in toxicology, 1993 - ACS Publications
… as DNA adducts (3-6) (Figure 1). Depending upon their structure, DNA adducts may (1) block
or significantly slow DNA … His group found that multiple adduct spots are detectable in DNA …
or significantly slow DNA … His group found that multiple adduct spots are detectable in DNA …