Recent developments in DNA adduct analysis using liquid chromatography coupled with mass spectrometry

Y Tang, JL Zhang - Journal of separation science, 2020 - Wiley Online Library
multiple DNA adducts in human lung tissue, and seven DNA … in the qualitative analysis of
DNA adducts utilizing LC-MS/MS … of low coverage for the analysis of multiple DNA adducts. …

[HTML][HTML] DNA adducts with lipid peroxidation products

IA Blair - Journal of Biological Chemistry, 2008 - ASBMB
… -mediated DNA damage. Unfortunately, to date, the analysis of urinary DNA adducts of lipid
… ONE-derived DNA adducts, which can arise only from lipid peroxidation, have now been …

Interindividual variations in DNA adduct levels assessed by analysis of multiple genetic polymorphisms in smokers

HB Ketelslegers, RWH Gottschalk… - … Biomarkers & Prevention, 2006 - AACR
… in DNA adduct levels in smokers (9). Thus, studies investigating single polymorphisms in
relation to DNA adduct … of multiple genotypes yields a better prediction of DNA adduct levels in …

Identification and quantitation of DNA adducts from calf thymus DNA exposed to 3, 4-epoxy-1-butene.

N Tretyakova, Y Lin, R Sangaiah, PB Upton… - …, 1997 - academic.oup.com
DNA HPLC/UV analysis of neutral thermal hydrolysates of EBtreated calf thymus DNA
showed the presence of four DNA adduct … Quantitative analysis repeated multiple times using …

Acetaldehyde and the genome: beyond nuclear DNA adducts and carcinogenesis

PJ Brooks, S Zakhari - Environmental and molecular …, 2014 - Wiley Online Library
… is technically laborious, which discourages testing adducts in multiple sequence contexts.
An alternative strategy to test multiple DNA sequence contexts involves treating a replication …

Formation and persistence of DNA adducts in different target tissues of rats after multiple administration of benzo[a]pyrene

SX Qu, NH Stacey - Carcinogenesis, 1996 - academic.oup.com
… 1 or adduct 4 for the entire post-exposure period. These results indicate that B[a]P … DNA
adduct levels in all tissues tested and that total adducts in PBMNs reflect total lung adduct levels. …

Liquid chromatography-electrospray ionization-mass spectrometry: the future of DNA adduct detection

R Singh, PB Farmer - Carcinogenesis, 2006 - academic.oup.com
… individual person on the basis of DNA adduct levels is so far not well advanced, as difficulties
may be encountered in some cases because of the multi-stage nature of the carcinogenic …

In vivo DNA adduct formation by bisphenol A

A Atkinson, D Roy - Environmental and Molecular Mutagenesis, 1995 - Wiley Online Library
… This is presumably an indication of accumulation of adducts as a result of multiple BPA
exposure. … and in vivo as liver DNA adducts observed in this study also supports this concept. …

Formation of DNA and hemoglobin adducts of fluoranthene after single and multiple exposures

NJ Gorelick, DA Hutchins, SR Tannenbaum… - …, 1989 - academic.oup.com
… -DNA adducts were not present at detectable levels in liver or kidney 24 h after one dose;
low levels of adducts … hemoglobin adducts as a surrogate for measurement of DNA adducts. …

DNA adducts and carcinogenesis

FA Beland, MC Poirier - The Pathobiology of Neoplasia, 1989 - Springer
… the DNA adducts obtained … the DNA adducts resulting from this metabolism, We then consider
the alterations that result within DNA when these lesions are replicated, and when multiple