Simultaneous quantitation of 14 DNA alkylation adducts in human liver and kidney cells by UHPLC-MS/MS: application to profiling DNA adducts of genotoxic reagents
Y Tang, Z Wang, M Li, R Zhang, J Zhang - Journal of Pharmaceutical and …, 2019 - Elsevier
… This study provides the basis for future method development to study multiple alkylation
DNA adducts, and approaches for genotoxic impurities risk and cancer risk evaluations. …
DNA adducts, and approaches for genotoxic impurities risk and cancer risk evaluations. …
Linking DNA adduct formation and human cancer risk in chemical carcinogenesis
MC Poirier - Environmental and molecular mutagenesis, 2016 - Wiley Online Library
… levels with exposure that can be impacted by multiple factors, including physical locality, …
DNA adduct formation and the timing of DNA adduct removal. For removal of PAH-DNA adducts …
DNA adduct formation and the timing of DNA adduct removal. For removal of PAH-DNA adducts …
DNA adducts and their biological relevance
G Doerjer, MA Bedell, F Oesch - Mutations in man, 1984 - Springer
… focussed on interactions of chemical carcinogens with DNA. DNA adducts of a variety of
chemical … The validity of the somatic mutation theory and the importance of DNA adducts to the …
chemical … The validity of the somatic mutation theory and the importance of DNA adducts to the …
DNA Adducts in Cancer Chemotherapy
Y Li - Journal of Medicinal Chemistry, 2024 - ACS Publications
… In the plasma cells of 12 patients with multiple myeloma, DNA interstrand cross-links were …
of melphalan–DNA mono and cross-link adducts in PBMCs of multiple myeloma patients. The …
of melphalan–DNA mono and cross-link adducts in PBMCs of multiple myeloma patients. The …
Correlation of DNA adduct levels with tumor incidence: carcinogenic potency of DNA adducts
M Otteneder, WK Lutz - Mutation Research/Fundamental and Molecular …, 1999 - Elsevier
… DNA-reactive carcinogens usually result in multiple adducts. The number can span from
a few (eg, aromatic amines) to more than a dozen (eg, small methylating agents such as the …
a few (eg, aromatic amines) to more than a dozen (eg, small methylating agents such as the …
DNA adducts and chronic degenerative diseases. Pathogenetic relevance and implications in preventive medicine
S De Flora, A Izzotti, K Randerath, E Randerath… - … Research/Reviews in …, 1996 - Elsevier
… Their control is exceedingly difficult due to their multiplicity and diversity, the interconnection
with a network of multiple risk factors and protective factors, the long latency and multistep …
with a network of multiple risk factors and protective factors, the long latency and multistep …
Characterization of covalent adriamycin-DNA adducts
SM Zeman, DR Phillips… - Proceedings of the …, 1998 - National Acad Sciences
… We have isolated and purified this adduct … -DNA adduct is structurally equivalent to that
resulting from direct reaction with formaldehyde. Covalent linkage of the drug to one of the DNA …
resulting from direct reaction with formaldehyde. Covalent linkage of the drug to one of the DNA …
Formation and persistence of arylamine DNA adducts in vivo.
FA Beland, FF Kadlubar - Environmental Health Perspectives, 1985 - ehp.niehs.nih.gov
… L., and Jackson, CD Persistence of DNA adducts in rat liver and kidney after multiple
doses of the carcinogen N-hydroxy-2-acetylaminofluorene. Cancer Res. 42: 1348-1354 (1982). …
doses of the carcinogen N-hydroxy-2-acetylaminofluorene. Cancer Res. 42: 1348-1354 (1982). …
Adducts to nuclear DNA and mitochondrial DNA as biomarkers in chemoprevention.
S De Flora, R Balansky, L Scatolini… - IARC Scientific …, 1996 - europepmc.org
… radioactive zones and multiple DNA adducts were revealed by 32P… Our working hypothesis
is that DNA adducts in trachea/lung, … DNA adducts were consistently detectable in the DNA of …
is that DNA adducts in trachea/lung, … DNA adducts were consistently detectable in the DNA of …
Current and future methodology for quantitation and site-specific mapping the location of DNA adducts
… B[a]P treatment however has been shown to also induce oxidative stress, which is known
to cause multiple DNA lesions recognized by the UvrABC Nuclease, potentially confounding …
to cause multiple DNA lesions recognized by the UvrABC Nuclease, potentially confounding …