… This study provides the basis for future method development to study multiple alkylation
DNA adducts, and approaches for genotoxic impurities risk and cancer risk evaluations. …

… levels with exposure that can be impacted by multiple factors, including physical locality, …
DNA adduct formation and the timing of DNA adduct removal. For removal of PAH-DNA adducts …

… focussed on interactions of chemical carcinogens with DNA. DNA adducts of a variety of
chemical … The validity of the somatic mutation theory and the importance of DNA adducts to the …

… In the plasma cells of 12 patients with multiple myeloma, DNA interstrand cross-links were …
of melphalan–DNA mono and cross-link adducts in PBMCs of multiple myeloma patients. The …

… DNA-reactive carcinogens usually result in multiple adducts. The number can span from
a few (eg, aromatic amines) to more than a dozen (eg, small methylating agents such as the …

… Their control is exceedingly difficult due to their multiplicity and diversity, the interconnection
with a network of multiple risk factors and protective factors, the long latency and multistep …

… We have isolated and purified this adduct … -DNA adduct is structurally equivalent to that
resulting from direct reaction with formaldehyde. Covalent linkage of the drug to one of the DNA …

… L., and Jackson, CD Persistence of DNA adducts in rat liver and kidney after multiple
doses of the carcinogen N-hydroxy-2-acetylaminofluorene. Cancer Res. 42: 1348-1354 (1982). …

… radioactive zones and multiple DNA adducts were revealed by 32P… Our working hypothesis
is that DNA adducts in trachea/lung, … DNA adducts were consistently detectable in the DNA of …

… B[a]P treatment however has been shown to also induce oxidative stress, which is known
to cause multiple DNA lesions recognized by the UvrABC Nuclease, potentially confounding …