… molecular mechanisms of Sirt1 activation and the effect of Sirt1 on endothelial protection. …
FOXO1 directly activated Sirt1 expression in vascular smooth muscle cells and HEK293 cells. …

… SIRT1 is a longevity regulator … in endothelial SIRT1-mediated vasodilator responses in the
arteries of young and old mice. In particular, the contributions of nitric oxide (NO), endothelial …

… : Vascular smooth muscle cells (… muscle SIRT1 on the functions of endothelial cells (ECs)
has not been well clarified. Here, we explored the role of smooth muscle SIRT1 in endothelial …

… Overexpression of SIRT1 in endothelial cells does not change eNOS function but … Endothelial
SIRT1 regulates the gene expression and protein stability of sGC in smooth muscle cells …

… Specifically, in the context of cardiovascular disease, SirT1 functions to upregulate endothelial
nitric oxide synthase, reduce serum lipid levels, and decrease inflammatory cytokines (18)…

… functions of SIRT1 against VSMC senescence, and summarize the contribution of SIRT1
derived … The mutual promotion between SIRT1 and eNOS improves the endothelial function and …

… demonstrate that SIRT1 plays a fundamental role in regulating endothelial NO and
endothelium-… of CR on the endothelium and vascular tone to SIRT1-mediated deacetylation of …

… that Sirt1 expression is reduced in endothelial cells obtained from … endothelial Sirt1 expression
with aging may be related to … in smooth muscle cells, endothelial cells and macrophages, …

… Large arteries are rich in elastin and collagen, whereas small muscular arteries are rich in
vascular smooth muscle cells. Elastin fibers determine the mechanical strength of the blood …

… growth factor and the defects of TGFβ-mediated vascular smooth muscle cell recruitment.
These limited information suggest that loss of LKB1 increases angiogenic potential at least in …