Modulation of neuronal stem cell differentiation by hypoxia and reactive oxygen species

HLA Vieira, PM Alves, A Vercelli - Progress in neurobiology, 2011 - Elsevier
… of human embryonic stem cells; the main focus of this review is to summarize the role of
oxygen during neuronal differentiation, in particular in response to oxygen level variation. …

Metabolic oxidation regulates embryonic stem cell differentiation

O Yanes, J Clark, DM Wong, GJ Patti… - Nature chemical …, 2010 - nature.com
… embryonic stem cells while monitoring the effects on differentiation. … ), promoted neuronal
and cardiac differentiation. We postulate … sustained by stem cells allows them to differentiate in …

[HTML][HTML] Oxidative stress promotes exit from the stem cell state and spontaneous neuronal differentiation

Q Hu, P Khanna, BSE Wong, ZSL Heng… - Oncotarget, 2018 - ncbi.nlm.nih.gov
… is a common cause of neuronal differentiation in stem cells, we next examined the effect of
GSH on atRA-mediated neuronal differentiation by co-treating NT2 cells with GSH and atRA, …

Endogenous reactive oxygen species are essential for proliferation of neural stem/progenitor cells

M Yoneyama, K Kawada, Y Gotoh, T Shiba… - Neurochemistry …, 2010 - Elsevier
It is widely thought that accumulation of reactive oxygen species (ROS) causes injury to cells
of neural stem/progenitor cells derived from the hippocampus of embryonic mice. The cells

Reactive oxygen species modulate the differentiation of neurons in clonal cortical cultures

M Tsatmali, EC Walcott, H Makarenkova… - Molecular and Cellular …, 2006 - Elsevier
differentiation of embryonic cortical progenitors. We report that rat cortical progenitors in
clonal culture produce two types of neurons … the differentiation of the two types of neurons. The …

Enhanced differentiation of neural stem cells to neurons and promotion of neurite outgrowth by oxygen–glucose deprivation

Q Wang, L Yang, Y Wang - International Journal of Developmental …, 2015 - Elsevier
… , differentiation and NSC-derived neurite outgrowth. We establish the culture of adult neural
stem cells … How OGD treatments regulate NSC’s cell viability, survival and differentiation, as …

Reactive oxygen species and the neuronal fate

KAM Kennedy, SDE Sandiford, IS Skerjanc… - Cellular and Molecular …, 2012 - Springer
cells differentiate into neurons in … neuronal differentiation [71–75], our work provided the
first demonstration that Nip can regulate neurogenesis in stem cells by regulating the cellular

Roles of reactive oxygen species in the fate of stem cells

P Chaudhari, Z Ye, YY Jang - Antioxidants & redox signaling, 2014 - liebertpub.com
… Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal …
Embryonic stem cell differentiation into smooth muscle cells is mediated by Nox4-produced …

Mitochondrial DNA damage level determines neural stem cell differentiation fate

W Wang, Y Esbensen, D Kunke… - Journal of …, 2011 - Soc Neuroscience
… pathways determining the differentiation fate being neurons or astrocytes (… oxygen species
(ROS) levels can alter differentiation fate of mouse progenitor cells toward either neuronal

The role of oxygen in regulating neural stem cells in development and disease

DM Panchision - Journal of cellular physiology, 2009 - Wiley Online Library
… ), thereby blocking terminal differentiation of neural precursors. Increased O 2 derepresses
p53 (dotted lines), which can lead to p21 cip1 -mediated cell differentiation or apoptosis. In …