… Neuropeptide Y (NPY) is the most abundant peptide present … effects are mediated by four
different receptor subtypes, Y-1, … of additional NPY receptor subtypes. Pharmacological studies …

… hormones as their ligands. Since 2000, the cDNAs of most of these candidate receptors have
been cloned and for many receptors the … neuropeptide and protein hormone receptors, and …

… and hormone overproduction. Our microarray results have also demonstrated a differential
expression of neuropeptide hormone receptors … analysis of relevant receptors in both human …

… The signal‐transducing receptors for metazoan neuropeptides and peptide hormones
can … ion channels, (2) heptahelical receptors (seven transmembrane [7TM] or G protein–coupled …

… The recent identification of, often multiple, receptor subtypes for each peptide, as well as the
… explore functional roles of neuropeptides. A characteristic of neuropeptides is the plasticity …

… Evaluation of the evolution of neuropeptides and their receptors … neuropeptide sequences
and the Y4 receptor supports this view. In general terms for both neuropeptides and receptors, …

… Similar GnRH receptors and their mRNA transcripts were … Activation of these neuronal GnRH
receptors elicited dose-… and synchronized discharge of the neuropeptide, could reflect the …

… From the above-mentioned examples we can see that there can be rapid neuropeptide/receptor
co-evolution. This rapid evolution can wash-out clear structural relationships between …

… third includes the glycoprotein hormone receptors (LSHR, FSHR, and TSHR). Fsh is located
at the base of a branch leading to the glycoprotein hormone receptors, indicating that this …

… For example, the parathyroid hormone receptor 1 (PTHR1) … receptors for neuropeptides
from the chordate Ciona intestinalis Type A, an important organism for the study of neuropeptide …