… , lung disease that mimics that in humans with cystic fibrosis occurs … origins and initiating
factors in cystic fibrosis lung disease probably determine the progression, severity, and disease …

… Further, symptoms of asthma may be absent or difficult to separate from the CF lung disease
itself. Some patients with CF and a family history of asthma may exhibit recurrent acute …

… Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung
disease suggest ongoing infection and inflammation. … Cleavage of CXCR1 on neutrophils …

… a prominent role in therapy early in the history of the disease. Humidification, by aerosol and
… When the next centennial edition is written, perhaps we can relegate the lung disease of CF …

… to explain the defects causing CF lung disease, to summarize our current knowledge of CF
… explains the basic cellular defect at the origin of our understanding of CF pathophysiology. …

… cystic fibrosis (CF), the pathogenesis of CF lung disease remains obscure. The elucidation of
the pathogenesis of CF lung disease … of the cystic fibrosis transmembrane regulator protein (…

… natural history of early lung disease; (… lung disease begins very early in life in cystic fibrosis
(CF), although it is initially “silent” without overt signs and symptoms of a progressive disease …

… — two traits that define lung disease in cystic fibrosis. Cystic fibrosis transmembrane conductance
… ) — two conditions that have features in common with cystic fibrosis lung disease. Two …

… disease can be traced back well into the Middle Ages. This review begins with the origins of
recognition of the symptoms of this genetic disease … to associate lung disease with diarrhea …

… cystic fibrosis is not well defined. To examine the natural history of inflammation and infection
in the CF lung … children with cystic fibrosis at a very early stage of their disease when they …