p-Toluenesulfonic acid-promoted selective functionalization of unsymmetrical arylalkynes: a regioselective access to various arylketones and heterocycles
M Jacubert, O Provot, JF Peyrat, A Hamze, JD Brion… - Tetrahedron, 2010 - Elsevier
Regioselective hydration of a wide range of internal alkynes has been afforded in high to
good yields by using PTSA in EtOH. The scope of the reaction of alkynes has been
delineated. Arylaliphatic alkynes and diarylalkynes were regioselectively hydrated in good
to excellent yields and short reaction times when the reaction was achieved under
microwave irradiation. Moreover, diarylalkynes, arylenynes as well as diaryldiynes bearing a
methoxy-or a thiomethyl substituent on the ortho position underwent a regioselective 5-endo …
good yields by using PTSA in EtOH. The scope of the reaction of alkynes has been
delineated. Arylaliphatic alkynes and diarylalkynes were regioselectively hydrated in good
to excellent yields and short reaction times when the reaction was achieved under
microwave irradiation. Moreover, diarylalkynes, arylenynes as well as diaryldiynes bearing a
methoxy-or a thiomethyl substituent on the ortho position underwent a regioselective 5-endo …
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