… and leukemogenesis. Here, we summarize the biological functions of P2X7 receptor during
both normal hematopoiesis and leukemogenesis. In particular, we found that ATP levels are …

… Stimulation of the P2X7 receptor by ATP caused post-translational processing of precursors
of IL-1β and IL-18 in human monocytes [7], [8], stimulation of JNK activity and induction of …

… The participation of the P2X7 receptor in hematopoiesis has also been demonstrated. The
… leukemia-AML) lineages. In HL-60 and J6-1 (myeloid leukemia) lineages, the P2X7 receptor …

… Acute myeloid leukemia (AML) is a hematopoietic stem cell … Approximately 50% of leukemia
patients survive their disease… the major limiting factors in leukemia treatment. Despite the …

… The activation of P2X receptors resulted influx of extracellular … of P2X7 receptor was
described. For instance, an N187D point mutation was detected in P2X7 receptor from a leukemia …

… leukemogenesis have not been established. In this study, the expression of P2X7 in
hematopoietic … Significance of P2X7 receptor variants to human health and disease. Recent …

… decided to examine the function of P2X7 during leukemogenesis. We first examined the
mRNA levels of P2x7 in both normal hematopoietic cells and leukemia cells. Interestingly, the …

… We previously demonstrated that ATP is a potent stimulator of normal hematopoietic stem
cell compartment while inhibiting acute myeloid leukemia (AML) cells. Based on this …

… P2X4 receptors, which shows ~50% sequence similarity to P2X7 … receptor antagonist
PSB12054 as well as P2X4-KO mice, we found that the P2X4 receptor, similar to P2X7 receptor, …

… P2X7 expression on HSCs and HSPCs in response to genotoxic stress. We further demonstrate
the role of P2X7 in hematopoietic … leukemia-initiating cells and to inhibit leukemogenesis …