… Unlike many cancers, the pattern of tumor evolution in papillary thyroid cancer (PTC) and
its … and spatial framework within which subclonal mutations catalyze tumor evolution and its …

… genes and signal pathways during progression of papillary thyroid cancer (PTC) via next-…
Direct Sanger sequencing was applied to validate the identified mutations. Results: Among …

… cancers. The aim of the present study was to determine the frequency of BRAF mutations in
thyroid cancer … six human thyroid cancer cell lines and 207 paraffin-embedded thyroid tumor …

… presenting annually (seer.cancer.gov). The most common form of thyroid cancer is papillary
thyroid cancer (PTC), comprising 65–88% of all differentiated thyroid cancers (1). Although …

… ) with papillary thyroid cancer (PTC), and different mutations … However, BRAF mutations have
not been adequately studied … None of our PTC (0/10) contained ras mutations, but 7/12 (58…

… mutation was higher in conventional papillary thyroid cancer (… papillary thyroid cancer (24.1%)
and follicular thyroid cancer (… conventional papillary thyroid cancer, BRAF V600E mutation …

… To discover driver mutations in thyroid cancers, we applied additional filtration criteria to
variant calls, as follows: 1) not or rarely shown in public databases of normal individuals, such …

… In conclusion, we found higher rates of BRAF V600E mutation over a 15-… mutations in
papillary thyroid cancer thus may contribute to the increasing incidence of papillary thyroid cancer. …

… The BRAF V600E mutation is the most common genetic alteration found in papillary thyroid
cancer (PTC). Recent studies show that this mutation occurs more frequently in patients with …

… (PTC), which accounts for 80% to 90% of all thyroid … thyroid cancer, 17,18 the oncogenic
T1799A BRAF mutation has been widely found in PTC and in some anaplastic thyroid cancers …