Roles of PI3K/AKT/GSK3/mTOR pathway in cell signaling of mental illnesses

Y Kitagishi, M Kobayashi, K Kikuta… - Depression research …, 2012 - Wiley Online Library
PI3K/AKT and GSK3 pathways may constitute an important signaling center in the subcellular
integration of the synaptic neurotransmission. The pathways … the PI3K/AKT/GSK3 pathways

Roles of PI3K/AKT/GSK3 pathway involved in psychiatric illnesses

S Matsuda, Y Ikeda, M Murakami, Y Nakagawa, A Tsuji… - Diseases, 2019 - mdpi.com
… the PI3K/AKT/GSK3 pathway may organize an intracellular central network for the action of
the synaptic neuroplasticity. In addition, the pathways … of the PI3K/AKT/GSK3 pathways in cell …

Regulation of PI3K/Akt/GSK3 pathway by cannabinoids in the brain

A Ozaita, E Puighermanal… - Journal of …, 2007 - Wiley Online Library
… and identifying methods capable of diminishing the deleterious impact of GSK-3 in … of the
PI3K/Akt/GSK-3 pathway. We found a close regulation of Akt and GSK-3 phosphorylation by …

GSK3 and its interactions with the PI3K/AKT/mTOR signalling network

MA Hermida, JD Kumar, NR Leslie - Advances in biological regulation, 2017 - Elsevier
… Therefore, a major role of GSK3 can be viewed as an amplifier of the … GSK3 regulation
and function, and the functions of GSK3 as it integrates with signalling through the PI3K-AKT

Interleukin‐10‐induced gene expression and suppressive function are selectively modulated by the PI3KAktGSK3 pathway

TT Antoniv, LB Ivashkiv - Immunology, 2011 - Wiley Online Library
… (PI3K) -mediated signalling regulates inflammatory responses and can induce IL-10 production,
but a role for PI3K … the involvement of the PI3K-Akt-GSK3 signalling pathway in IL-10-…

AKT/GSK3 signaling pathway and schizophrenia

ES Emamian - Frontiers in molecular neuroscience, 2012 - frontiersin.org
… signaling pathways in schizophrenia. In this review, we mainly focus on AKT/GSK3 signaling
pathway in … AKT is activated by PI3K, which itself is activated by several upstream signaling …

Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer's disease

Y Kitagishi, A Nakanishi, Y Ogura… - Alzheimer's research & …, 2014 - Springer
… This pathway appears to be … the PI3K/AKT/GSK-3β pathways in cell signaling of neuronal
cells. We also review recent studies on the features of several diets and the signaling pathway

LY3023414 inhibits both osteogenesis and osteoclastogenesis through the PI3K/Akt/GSK3 signalling pathway

X Chen, W Chen, ZM Aung, W Han… - Bone & Joint …, 2021 - boneandjoint.org.uk
Aims LY3023414 is a novel oral phosphatidylinositol 3-kinase (PI3K)/mammalian target of
rapamycin (mTOR) dual inhibitor designed for advanced cancers, for which a phase II clinical …

Inhibition of the PI3K/Akt/GSK3 pathway downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD downregulates DNA damage-induced Chk1 activation as well as G2/M …

T Kurosu, T Nagao, N Wu, G Oshikawa, O Miura - PloS one, 2013 - journals.plos.org
… by inactivating GSK3 through the PI3K/Akt signaling pathway to … The PI3K inhibitor GD-0941
or the Akt inhibitor MK-2206 … GSK3 inhibitors, including LiCl and SB216763, restored the …

Insulin promotes mitochondrial respiration and survival through PI3K/AKT/GSK3 pathway in human embryonic stem cells

Z Ren, H Zhong, C Song, C Deng, HT Hsieh, W Liu… - Stem cell reports, 2020 - cell.com
PI3K/AKT activation and downstream GSK3 inhibition. We further show that insulin acts
through GSK3 … This study uncovers a critical role of the AKT/GSK3 pathway in the regulation of …