Objectives Cefazolin is frequently administered for antimicrobial prophylaxis and treatment
of infections. In neonates, pharmacokinetic observations are limited and dosing regimens
variable. The aim of this study was to describe the pharmacokinetics of cefazolin in neonates
based on total and unbound concentrations to optimize cefazolin dosing. Methods Thirty-six
neonates [median birth body weight 2720 (range 540–4200) g, current body weight (cBW)
2755 (830–4200) g and postnatal age (PNA) 9 (1–30) days] receiving intravenous cefazolin …

Objective This study's objective was to describe the population pharmacokinetics of total and
unbound flucloxacillin in non-critically ill patients, and to devise a rational continuous dosing
regimen for this population. Methods Total and unbound flucloxacillin pharmacokinetics in
30 non-critically ill patients receiving intravenous flucloxacillin were analysed using non-
linear mixed-effects modelling. Monte Carlo simulation was used to assess the fraction of the
population reaching effective unbound flucloxacillin levels and the fraction reaching …