Therapeutic approaches to innate immunity: severe sepsis and septic shock

E Lolis, R Bucala - Nature reviews Drug discovery, 2003 - nature.com
… , are affording new opportunities for therapeutic development. … therapeutic intervention,
considers rationales for the resurrection of previously failed drugs, and highlights new targets

HSP-target of therapeutic agents in sepsis treatment

A Vulczak, CHR Catalão, LAP Freitas… - International Journal of …, 2019 - mdpi.com
… of treatment after sepsis. They also should consider the differences in experimental sepsis
… main results of studies on therapeutic agents in targeting HSPs in sepsis treatment. We also …

A new paradigm for the treatment of sepsis: is it time to consider combination therapy?

AS Cross, SM Opal - Annals of internal medicine, 2003 - acpjournals.org
… these patients susceptible to fatal infection. It is now time to test a new therapeutic paradigm
based on an improved understanding of the pathophysiology of the septic process and the …

Fibrinolytic alterations in sepsis: biomarkers and future treatment targets

JB Larsen, AM Hvas - Seminars in Thrombosis and Hemostasis, 2021 - thieme-connect.com
… To assess current literature on potential markers for altered fibrinolysis in sepsis, we performed
a literature search in PubMed and Embase on February 01, 2020. Studies were included …

A new perspective in sepsis treatment: could RGD-dependent integrins be novel targets?

D Nader, GF Curley, SW Kerrigan - Drug discovery today, 2020 - Elsevier
… could reduce the risk of developing septic shock. In this review, we demonstrated a potentially
new perspective in therapeutics against sepsis: integrin-based therapy. With regards to …

Sepsis and oxidative stress in the newborn: from pathogenesis to novel therapeutic targets

C Poggi, C Dani - Oxidative medicine and cellular longevity, 2018 - Wiley Online Library
… Therefore, antioxidant treatment would exert beneficial effects during neonatal sepsis, potentially
treatment. Among others, antioxidant agents investigated in clinical settings as adjunct …

Long noncoding RNA: regulatory mechanisms and therapeutic potential in sepsis

W Wang, N Yang, R Wen, CF Liu… - … in cellular and infection …, 2021 - frontiersin.org
treatment for sepsis, lncRNAs may be promising biomarkers and even targets for sepsis
therapies… the roles of lncRNAs in sepsis and sheds light on their use as potential biomarkers and …

Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?

L Van Wyngene, J Vandewalle… - EMBO molecular medicine, 2018 - embopress.org
septic organism copes with this schism, and whether these insights can lead to new
therapeutic … during sepsis and the possible consequences, we could be paving the way to a …

Postbiotics as potential new therapeutic agents for sepsis

X Lou, J Xue, R Shao, C Mo, F Wang, G Chen - Burns & trauma, 2023 - academic.oup.com
… and progression of sepsis, suggesting a potential new therapeutic target for sepsis. …
Although there is little research on postbiotics therapy for sepsis, we believe that this may …

Experimental and emerging therapies for sepsis and septic shock

RL Añel, A Kumar - Expert opinion on investigational drugs, 2001 - Taylor & Francis
… addressed element in the treatment of sepsis. The list of potential therapeutic targets has
been growing as more and more mediators are identified in the pathogenesis of sepsis. To date…