Metabolic inflammatory complex in sepsis: septic cachexia as a novel potential therapeutic target

M Kaneki - Shock, 2017 - journals.lww.com
… that septic cachexia may be a novel target disease state, which would help identify new
molecular targets to improve outcomes of septic … This possibility is discussed in light of new

Microglia: a potential therapeutic target for sepsis-associated encephalopathy and sepsis-associated chronic pain

Y Li, L Yin, Z Fan, B Su, Y Chen, Y Ma… - Frontiers in …, 2020 - frontiersin.org
… Thus, exploring the roles of microglia in SAE and long-term cognitive impairment will deepen
our understanding of pathology of SAE and probably offer a potential therapeutic target for …

The microcirculation as a therapeutic target in the treatment of sepsis and shock

VSK Edul, A Dubin, C Ince - Seminars in respiratory and critical …, 2011 - thieme-connect.com
… has provided the promise of identifying new therapeutic targets. Clinical research has
identified various conventional and new therapeutic approaches that are successful in modifying …

Cannabinoid receptor 2: a potential novel therapeutic target for sepsis?

Q He, F Xiao, Q Yuan, J Zhang, J Zhan… - Acta Clinica …, 2019 - Taylor & Francis
… This review discusses available data regarding the role of CB2R in sepsis and the possible
underlying mechanism. In summary, the accumulated evidence revealed that activating …

Long noncoding RNA: regulatory mechanisms and therapeutic potential in sepsis

W Wang, N Yang, R Wen, CF Liu… - … in cellular and infection …, 2021 - frontiersin.org
treatment for sepsis, lncRNAs may be promising biomarkers and even targets for sepsis
therapies… the roles of lncRNAs in sepsis and sheds light on their use as potential biomarkers and …

Immune checkpoints: novel therapeutic targets to attenuate sepsis-induced immunosuppression

MA McBride, TK Patil, JK Bohannon… - Frontiers in …, 2021 - frontiersin.org
… approved therapy currently exists to treat sepsis (9). Therefore, there is a critical need to
advance our … of sepsis pathology and identify novel biological targets for the development of new

[HTML][HTML] New paradigms in sepsis: from prevention to protection of failing microcirculation

J Hawiger, RA Veach, J Zienkiewicz - Journal of Thrombosis and …, 2015 - Elsevier
… in the first ‘golden hour’, including pre‐hospital settings, is the goal to avert widespread …
‐life (up to 29 h) 81 , further expands the potential of intracellular protein therapy for sepsis. …

Therapeutic targets and signaling mechanisms of vitamin C activity against sepsis: a bioinformatics study

R Li, C Guo, Y Li, Z Qin, W Huang - Briefings in bioinformatics, 2021 - academic.oup.com
… approach to reveal predictive targets and therapeutic mechanisms underlying the action of
VC against sepsis. We hope that the predictive targets and therapeutic mechanisms may be …

A new paradigm for the treatment of sepsis: is it time to consider combination therapy?

AS Cross, SM Opal - Annals of internal medicine, 2003 - acpjournals.org
… these patients susceptible to fatal infection. It is now time to test a new therapeutic paradigm
based on an improved understanding of the pathophysiology of the septic process and the …

Fibrinolytic alterations in sepsis: biomarkers and future treatment targets

JB Larsen, AM Hvas - Seminars in Thrombosis and Hemostasis, 2021 - thieme-connect.com
… To assess current literature on potential markers for altered fibrinolysis in sepsis, we performed
a literature search in PubMed and Embase on February 01, 2020. Studies were included …