… levels of HGF seem insufficient in septic rats, with a time lag … a candidate for the therapeutic
development of septic diseases (… as a new drug target in such a complex system as sepsis. …

… investigated for their potential as sepsis treatment, including … approved specifically for use
in sepsis before it was withdrawn from … as a potential therapeutic target rather than a treatment. …

… , are affording new opportunities for therapeutic development. … therapeutic intervention,
considers rationales for the resurrection of previously failed drugs, and highlights new targets …

… Still, we are struggling for the identification of a specific therapeutic target for the management
of sepsis in the clinics and intensive care units (ICUs) around the world. For example, data …

… as a potential therapeutic target also in human sepsis (5) … sepsis patients lay the groundwork
for the discussion of S1P being not only a potential new therapeutic target but also a sepsis …

… several new therapeutic targets such as 5-HT7 receptor agonist, salbutamol, aliskiren,
amiodarone, lithium, montelukast, alpha-lipoic acid, and sildenafil for sepsis treatment. The …

… for the treatment or prevention of human sepsis are available. The current modalities of therapy
in sepsis … if the IL-17 family and IL-23 become potential targets for in vivo neutralization. …

… New candidate targets for the treatment of sepsis are constantly being developed at the
bench. One of these agents is the immunostimulatory cytokine, interleukin 7 (IL-7), which …

… Among the current research goals, two pathways seem attractive. HMGB1 is a ubiquitous …
endotoxemia and sepsis. Several properties make this mediator a potential therapeutic target. …

… This insight has raised the prospect of new approaches to therapy that target the host
response, rather than the microorganism that elicited it, and has prompted an as yet unfinished re-…