The microcirculation as a diagnostic and therapeutic target in sepsis
A Nencioni, S Trzeciak, NI Shapiro - Internal and emergency medicine, 2009 - Springer
… the crucial role that microcirculation plays in sepsis. If not corrected, … as an important target
in the pathogenesis of sepsis and its … diagnostic and therapeutic target for treatment in sepsis. …
in the pathogenesis of sepsis and its … diagnostic and therapeutic target for treatment in sepsis. …
Immunomodulatory therapy for sepsis: an update
E Christaki, P Anyfanti, SM Opal - … review of anti-infective therapy, 2011 - Taylor & Francis
… As the pathophysiologic events that take place during sepsis are being elucidated, new
molecules that target each step of those pathways are being tested. However, a lot of those …
molecules that target each step of those pathways are being tested. However, a lot of those …
Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?
L Van Wyngene, J Vandewalle… - EMBO molecular medicine, 2018 - embopress.org
… septic organism copes with this schism, and whether these insights can lead to new
therapeutic … during sepsis and the possible consequences, we could be paving the way to a …
therapeutic … during sepsis and the possible consequences, we could be paving the way to a …
Heparin, heparan sulphate and sepsis: potential new options for treatment
J Hogwood, E Gray, B Mulloy - Pharmaceuticals, 2023 - mdpi.com
… Neutrophils are therefore a logical target for the treatment and perhaps prevention of sepsis
by attenuation of their release and activity. The results of the HETRASE trial [101] suggested …
by attenuation of their release and activity. The results of the HETRASE trial [101] suggested …
Broken barriers: a new take on sepsis pathogenesis
… sepsis. In this Perspective, we highlight the endothelial barrier as a new target for sepsis
therapeutics, examining three potential … Another potential therapeutic strategy for treating sepsis …
therapeutics, examining three potential … Another potential therapeutic strategy for treating sepsis …
[HTML][HTML] Sepsis—pathophysiology and therapeutic concepts
D Jarczak, S Kluge, A Nierhaus - Frontiers in medicine, 2021 - frontiersin.org
… has been disappointing, and the investigation of strategies aiming at re-balancing the
profound immune dysregulation during sepsis and septic shock seems to be a promising goal. …
profound immune dysregulation during sepsis and septic shock seems to be a promising goal. …
Therapeutic potential and limitations of cholinergic anti-inflammatory pathway in sepsis
A Kanashiro, F Sônego, RG Ferreira… - Pharmacological …, 2017 - Elsevier
… In this context, the present review describes the role of the efferent vagal transmission in
controlling inflammation during sepsis and highlights the pharmacologic targets that can be …
controlling inflammation during sepsis and highlights the pharmacologic targets that can be …
Sepsis under siege: a new understanding of sepsis might lead to the development of therapies to treat septic shock
P Hunter - EMBO reports, 2006 - embopress.org
… leading to a new generation of drugs capable of treating not only sepsis but also chronic …
forms of sepsis. Attention has therefore turned to new drugs that directly target cytokines or the …
forms of sepsis. Attention has therefore turned to new drugs that directly target cytokines or the …
Inner sensors of endotoxin–implications for sepsis research and therapy
T Skirecki, JM Cavaillon - FEMS Microbiology Reviews, 2019 - academic.oup.com
… These provide new potential targets for intervention in sepsis … knowledge on endotoxin
sensing in sepsis with special focus on … and discuss potential therapeutic approaches addressing …
sensing in sepsis with special focus on … and discuss potential therapeutic approaches addressing …
ALK is a therapeutic target for lethal sepsis
L Zeng, R Kang, S Zhu, X Wang, L Cao… - Science translational …, 2017 - science.org
… disease severity, prognosis, and potential future therapeutic targets in patients with sepsis
(34–36). Thus, to correlate symptoms with different phases of sepsis, it is important to survey …
(34–36). Thus, to correlate symptoms with different phases of sepsis, it is important to survey …