[HTML][HTML] Functional significance of exosomes applied in sepsis: a novel approach to therapy

J Wu, Y Wang, L Li - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2017 - Elsevier
… and sepsis and therapeutic use of exosomes in bacterially mediated inflammation or
sepsis. We evaluate exosomes as drug vehicles, including their therapeutic cargo, potential

Endothelium as a therapeutic target in sepsis

WC Aird - Current drug targets, 2007 - ingentaconnect.com
… the sepsis phenotype. The goals of this review are to discuss how endothelial cells
contribute to and are affected by sepsis, and to underscore potential targets for novel therapy. …

[HTML][HTML] Gaps and opportunities in sepsis translational research

JC Marshall, A Leligdowicz - EBioMedicine, 2022 - thelancet.com
therapeutic approaches and the feasibility of new approaches to evaluate them. We review
the history of mediator-targeted therapy for sepsistherapies that target the host response. …

A new perspective on the potential application of RIPK1 in the treatment of sepsis

X Wang, Y Chai, Z Guo, Z Wang, H Liao, Z Wang… - …, 2023 - Taylor & Francis
… properties of RIPK1 and explore its potential application in the treatment of sepsis. … a direct
target for sepsis treatment by delaying the progression of sepsis and providing more treatment

The pathophysiology and treatment of sepsis

RS Hotchkiss, IE Karl - New England journal of medicine, 2003 - Mass Medical Soc
therapies have demonstrated surprising efficacy. In this article, we examine evolving concepts
of sepsis and discuss new and potential therapies… , and early goal-directed therapy to treat …

Current murine models of sepsis

AJ Lewis, CW Seymour, MR Rosengart - Surgical infections, 2016 - liebertpub.com
… Yet, the search for new targets to enhance care for patients with sepsis continues. As it is
not feasible to test each potential new therapy immediately in human patients, researchers …

[HTML][HTML] Sepsis-associated liver injury: Mechanisms and potential therapeutic targets

JW Chen, CY Liu, S Li, SW Wu, C Cai… - World Journal of …, 2024 - wjgnet.com
… the gut-liver axis as a potential target for therapeutic intervention; simultaneously, the gut …
liver injury induced by polymicrobial sepsis, providing new insights for the treatment of SLI. …

Improvement of sepsis by hepatocyte growth factor, an anti‐inflammatory regulator: emerging insights and therapeutic potential

S Mizuno, T Nakamura - Gastroenterology Research and …, 2012 - Wiley Online Library
… levels of HGF seem insufficient in septic rats, with a time lag … a candidate for the therapeutic
development of septic diseases (… as a new drug target in such a complex system as sepsis. …

[HTML][HTML] Diagnostics, therapy and outcome prediction in abdominal sepsis: current standards and future perspectives

A Hecker, F Uhle, T Schwandner, W Padberg… - … archives of surgery, 2014 - Springer
… identification and implementation of an interdisciplinary therapy. The purpose of this review
on septic peritonitis is to give an update on the diagnosis and its evidence-based treatment. …

[HTML][HTML] Exploring the biomarkers and potential therapeutic drugs for sepsis via integrated bioinformatic analysis

P Liang, Y Wu, S Qu, M Younis, W Wang, Z Wu… - BMC Infectious …, 2024 - Springer
… with high expression values of these five hub genes had a better prognosis, suggesting
that these five hub genes may serve as important therapeutic targets or biomarkers for sepsis. …