Derivatives of piperazines as potential therapeutic agents for Alzheimer's disease
E Popugaeva, D Chernyuk, H Zhang… - Molecular …, 2019 - ASPET
… for development of AD therapeutic agents. In the current study, we … to study as potential
neuroprotective agents. We applied … potential lead molecules for development of AD therapeutic …
neuroprotective agents. We applied … potential lead molecules for development of AD therapeutic …
Heat shock proteins in health and disease: therapeutic targets or therapeutic agents?
AG Pockley - Expert reviews in molecular medicine, 2001 - cambridge.org
… reactivity to self-heat shock proteins can downregulate pathogenic processes all suggest a
potential role for heat shock proteins as therapeutic agents, rather than as therapeutic targets. …
potential role for heat shock proteins as therapeutic agents, rather than as therapeutic targets. …
Nrf2 Activator PB125® as a Potential Therapeutic Agent against COVID-19
JM McCord, BM Hybertson, A Cota-Gomez, KP Geraci… - Antioxidants, 2020 - mdpi.com
Nrf2 is a transcription factor that regulates cellular redox balance and the expression of a
wide array of genes involved in immunity and inflammation, including antiviral actions. Nrf2 …
wide array of genes involved in immunity and inflammation, including antiviral actions. Nrf2 …
Brain natriuretic peptide in pulmonary arterial hypertension: biomarker and potential therapeutic agent
B Casserly, JR Klinger - Drug design, development and therapy, 2009 - Taylor & Francis
… -hypertrophic agent and thus, may have therapeutic potential … disease and its potential
as a therapeutic agent for the … Finally, potential therapeutic applications for the treatment of …
as a therapeutic agent for the … Finally, potential therapeutic applications for the treatment of …
The need for new therapeutic agents: what is in the pipeline?
PM Shah - Clinical Microbiology and infection, 2005 - Wiley Online Library
… This article will summarise recently introduced agents and give examples of agents currently
in development, covering both new and existing mechanisms of action. Focus will be given …
in development, covering both new and existing mechanisms of action. Focus will be given …
4, 5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer
PA Brough, W Aherne, X Barril… - Journal of medicinal …, 2008 - ACS Publications
Inhibitors of the Hsp90 molecular chaperone are showing considerable promise as
potential chemotherapeutic agents for cancer. Here, we describe the structure-based design, …
potential chemotherapeutic agents for cancer. Here, we describe the structure-based design, …
Chemical and pharmacological chaperones as new therapeutic agents
TW Loo, DM Clarke - Expert reviews in molecular medicine, 2007 - cambridge.org
… A potential therapy for protein misfolding is to correct defective protein folding and … Therefore,
pharmacological chaperones show great promise as a new class of therapeutic agents that …
pharmacological chaperones show great promise as a new class of therapeutic agents that …
Important flavonoids and their role as a therapeutic agent
… Most of the flavonoids are widely accepted as therapeutic agents [6]. These are naturally
synthesized through the phenylpropanoid pathway with bioactivity dependent on its absorption …
synthesized through the phenylpropanoid pathway with bioactivity dependent on its absorption …
Iminosugars as therapeutic agents: recent advances and promising trends
… The field of iminosugars continues to open up exciting new opportunities for therapeutic
agent discovery and offers many new tools for precisely modifying carbohydrate structures and …
agent discovery and offers many new tools for precisely modifying carbohydrate structures and …
A data-driven drug repositioning framework discovered a potential therapeutic agent targeting COVID-19
… In summary, the PARP1 inhibitor CVL218 discovered by our data-driven drug repositioning
framework can serve as a potential therapeutic agent for the treatment of COVID-19. …
framework can serve as a potential therapeutic agent for the treatment of COVID-19. …