Molecular glue (MG) compounds are a type of unique small molecule that can change the
protein–protein … These small-molecule MGs are gradually being recognized for their …

… , it should be noted that other macromolecule, such as macrolides and peptides may also
have potential application prospects as molecular glues. Macrolides were the first …

… marketed drugs rely on small molecules with an ‘occupancy-… molecule drugs have been
successfully used as treatments for … to conventional small-molecule inhibitors. To pursue this …

… these molecules, with a special focus on molecular glues. We also outline the advantages of
the molecular glues … While many potential molecular glue compounds may come from drug …

… The concept of protein degradation is concerned with molecular glues, which form part of the
… in diseases, offering potential treatments for conditions that were previously difficult to treat. …

… of molecular glues and share our opinions on the identification of novel molecular glues in an
… as Thalidomide, which allows molecular glues to be regarded as potential and ideal drugs. …

… , molecular glues have exceptional promise as a therapeutic modality. (1) Thus far, molecular
glue … of how molecular glues can be utilized to induce the degradation of neosubstrates. …

… Interestingly, these conformational changes appear to be IMiDs-structure dependent,
revealing a huge potential for this class of molecules. IMiDs have been associated with the …

… In our Discussion and Outlook section below, we explore the untapped potential of type I
molecular glues for inhibiting therapeutically relevant PPIs and discuss promising IDM-based …

… proteins has now been achieved by molecular-glue-mediated proximity-induced …
molecular glue (MG) degraders targeting GSPT1 is a novel and promising approach for treating …