Preclinical pharmacology modeling of chimeric antigen receptor T therapies
R Kumari, X Ouyang, J Wang, X Xu, M Zheng… - Current Opinion in …, 2021 - Elsevier
… This review will discuss some relevant preclinical models for pharmacology assessment of
… Careful selection of the preclinical model based on the aims of the study can lead to better …
… Careful selection of the preclinical model based on the aims of the study can lead to better …
[HTML][HTML] Preclinical assessment of antigen-specific chimeric antigen receptor regulatory T cells for use in solid organ transplantation
E Proics, M David, M Mojibian, M Speck… - Gene Therapy, 2023 - nature.com
… of preclinical tests required for medicinal products containing genetically modified cells intended
for use in humans, to assess … an overview of key components of the preclinical package. …
for use in humans, to assess … an overview of key components of the preclinical package. …
Chimeric antigen receptor T cells for the treatment of cancer and the future of preclinical models for predicting their toxicities
A Wegner - Immunotherapy, 2017 - Taylor & Francis
… the use of chimeric antigen receptor (CAR) engineered T cells. In this approach, T cells
isolated from patients are engineered to express an activating fusion receptor that binds directly …
isolated from patients are engineered to express an activating fusion receptor that binds directly …
Preclinical models in chimeric antigen receptor–engineered T-cell therapy
EL Siegler, P Wang - Human gene therapy, 2018 - liebertpub.com
… this therapy, but equally crucial are the preclinical models used in testing CAR safety and …
Careful selection of the preclinical model based on the aims of the study (Table 1) can lead …
Careful selection of the preclinical model based on the aims of the study (Table 1) can lead …
Preclinical evaluation of chimeric antigen receptors targeting CD70-expressing cancers
QJ Wang, Z Yu, K Hanada, K Patel, D Kleiner… - Clinical Cancer …, 2017 - AACR
… In this study, we first evaluated the in vitro function of anti-human CD70 chimeric antigen
receptor (CAR) constructs by fusing different portions of CD27 with CD3-zeta in combination …
receptor (CAR) constructs by fusing different portions of CD27 with CD3-zeta in combination …
Construction and preclinical evaluation of an anti-CD19 chimeric antigen receptor
JN Kochenderfer, SA Feldman, Y Zhao… - Journal of …, 2009 - journals.lww.com
… genes of chimeric antigen receptors (CARs) that recognize tumor-associated antigens. We
constructed … We selected the CAR that did not contain the 4-1BB moiety for further preclinical …
constructed … We selected the CAR that did not contain the 4-1BB moiety for further preclinical …
[HTML][HTML] Preclinical safety evaluation of chimeric antigen receptor-modified T cells against CD19 in NSG mice
H Wen, Z Qu, Y Yan, C Pu, C Wang… - Annals of …, 2019 - ncbi.nlm.nih.gov
… preclinical safety assessment of CART19 was performed on NSG mice, to evaluate the
preclinical … Herein, a comprehensive preclinical safety assessment of CART19 was performed …
preclinical … Herein, a comprehensive preclinical safety assessment of CART19 was performed …
Preclinical evaluation of B7-H3–specific chimeric antigen receptor T cells for the treatment of acute myeloid leukemia
… We describe here the preclinical assessment of B7-H3–specific CAR T cells (B7-H3.CAR-T)
as a possible therapy for a subset of patients with AML and our evaluation of the potential …
as a possible therapy for a subset of patients with AML and our evaluation of the potential …
Preclinical assessment of suitable natural killer cell sources for chimeric antigen receptor natural killer–based “Off-the-Shelf” acute myeloid leukemia immunotherapies
S Kloess, O Oberschmidt, J Dahlke, XK Vu… - Human Gene …, 2019 - liebertpub.com
… with chimeric antigen receptors (CARs) designed to target tumor-specific antigens and
enhance NK cell-mediated anticancer activity. CARs are synthetic receptors that consist of a …
enhance NK cell-mediated anticancer activity. CARs are synthetic receptors that consist of a …
[HTML][HTML] Systematic preclinical evaluation of CD33-directed chimeric antigen receptor T cell immunotherapy for acute myeloid leukemia defines optimized construct …
… We systematically compared the preclinical in vitro and in vivo efficacy of T … antigen for
potential immunotherapeutic targeting in patients with AML. Based on this rigorous preclinical …
potential immunotherapeutic targeting in patients with AML. Based on this rigorous preclinical …
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- chimeric antigen receptor
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