… and early embryos and is responsible for establishing methylation at … at later stages of
pre-implantation embryos development, … for remethylation following embryonic reprogramming. …

… embryo development at the methylation level. In conclusion, we report a detailed analysis
of the DNA methylation dynamics during the development of sheep preimplantation embryos. …

… The changes in the levels of DNA methylation have been analyzed by immunofluorescence,
… These studies have revealed that, although global levels of DNA methylation decrease until …

… Similar to the pre-implantation embryo, global DNA demethylation in PGCs is mostly passive.
Following PGC specification, transcription of de novo methyltransferases Dnmt3a and 3b …

… during preimplantation embryo development could cause significant modifications of the DNA
methylation … to explore the global DNA methylation patterns of the blastocysts derived from …

… , indicating establishment of the variable methylation state in the preimplantation embryo,
before gastrulation (7). Murine and human MEs have been associated with the presence of …

… preimplantation development. Here we provide an insight that epigenetic reprogramming of
DNA methylation … To address this hypothesis, methylation states of three repetitive genomic …

… preimplantation embryo development, as well as interactions between epigenetic and genetic
regulation in these early developmental stages. … on the effects of DNA methylation [10, 11] …

… DNA methylation marks at key regulators of pluripotency are erased in the early embryo, a
process which is critical for early development … methylation in preimplantation embryos of the …

… DNA methylation patterns during embryo development play a role in reprogramming the
genome in the developing embryo. … global de nuuo methylation in the preimplantation embryo. …