Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials

JA Staessen, J Gasowski, JG Wang, L Thijs… - The Lancet, 2000 - thelancet.com
… Drug treatment is justified in older patients with isolated systolic hypertension whose
systolic blood pressure is 160 mm Hg or higher. Absolute benefit is larger in men, in …

Thalidomide for previously untreated elderly patients with multiple myeloma: meta-analysis of 1685 individual patient data from 6 randomized clinical trials

, … Network, Turkish Myeloma Study Group … - Blood, The Journal …, 2011 - ashpublications.org
… We conclude that thalidomide added to MP improves OS and PFS in previously untreated
elderly patients with multiple myeloma, extending the median survival time by on average 20%…

MP versus MPT for previously untreated elderly patients with multiple myeloma: A meta-analysis of 1,682 individual patient data from six randomized clinical trials.

A Waage, AP Palumbo, P Fayers, M Beksac… - Journal of Clinical …, 2010 - ascopubs.org
8130 Background: Randomized clinical trials including previously untreated patients were
initiated in Italy, France (2), Netherlands/Belgium, and Nordic countries in 2000-2002 and in …

Systematic review with metaanalysis: inflammatory bowel disease in the elderly

JP Gisbert, M Chaparro - Alimentary pharmacology & …, 2014 - Wiley Online Library
… The World Health Organization defines elderly persons as those aged ≥65 years; however,
… in the risk of infection in older patients.141 In this study, azathioprine appeared to be better …

A network meta-analysis of therapies for previously untreated chronic lymphocytic leukemia

MM Cheng, B Goulart, DL Veenstra, DK Blough… - Cancer treatment …, 2012 - Elsevier
… We conducted a network meta-analysis using fixed and random … study was to conduct a
network meta-analysis to compare relative treatment effects of therapies for previously untreated

Treatment of hypertension in patients 80 years and older: the lower the better? A meta-analysis of randomized controlled trials

T Bejan-Angoulvant, M Saadatian-Elahi… - Journal of …, 2010 - journals.lww.com
… In conclusion, particular attention should be given to hypertensive elderly patients who
constitute a large, growing and vulnerable population. Treating hypertension in very old …

[HTML][HTML] Efficacy outcomes in the treatment of older or medically unfit patients with acute myeloid leukaemia: a systematic review and meta-analysis

A Stone, T Zukerman, L Flaishon, RB Yakar… - Leukemia Research, 2019 - Elsevier
in older patients with CD33 positive AML cells, based on improvement in Median OS from
3.6 in the control best supportive care arm (n = 119) to 4.9 months in the GO arm (n = 118), HR …

Meta-analysis of molecular targeted agents in the treatment of elderly patients with metastatic colorectal cancer: Does the age matter?

CJ Zhao, SL Li, Q Liu - Journal of Cancer Research and …, 2018 - journals.lww.com
… In conclusion, this is the first-meta-analysis to specifically assess the role of MTAs in the
treatment of elderly patients with mCRC. Our study confirms that the addition of MTAs to the …

[HTML][HTML] The efficacy of immune checkpoint inhibitors in elderly patients: a meta-analysis and meta-regression

CM Kim, JB Lee, SJ Shin, JB Ahn, M Lee, HS Kim - ESMO open, 2022 - Elsevier
… Immune checkpoint inhibitor (ICI) therapy has improved patient survival in advanced … ICIs
in elderly patients is still elusive. This study assessed the efficacy of ICIs in elderly patients with …

A systematic literature review and network meta-analysis of treatments for patients with untreated multiple myeloma not eligible for stem cell transplantation

K Weisel, C Doyen, M Dimopoulos, A Yee… - Leukemia & …, 2017 - Taylor & Francis
… survival endpoints in previously untreated MM patients ineligible for ASCT. In this analysis,
Rd … However, the OS benefit in the VMP group did not apply to elderly patients (≥75 years).[…