… progressive stages of the disease. We propose that the inflammatory demyelinating disease
process in early multiple sclerosis … that treatment of progressive multiple sclerosis should be …

… inflammatory process and pathogenetic mechanisms in multiple sclerosis (MS). … progressive
MS and discusses new data on the mechanisms underlying its pathogenesis. In progressive …

… Therefore, the half of patients with multiple sclerosis who have progressive disease have …
of how we can help patients with primary progressive multiple sclerosis (PPMS) and SPMS. …

… Relapsing/remitting multiple sclerosis (RRMS) appears to be largely … progressive disease
(primary progressive multiple sclerosis, PPMS and secondary progressive multiple sclerosis, …

About 10–15% of patients with multiple sclerosis (MS) present with gradually increasing
neurological disability, a disorder known as primary-progressive multiple sclerosis (PPMS). …

… may be key processes in progressive disease. Interfering with these … clinical trials in
progressive multiple sclerosis have yielded … involved in progressive multiple sclerosis, correlations …

… patients with secondary progressive multiple sclerosis of similar physical disability. They
suggest that this relates to progressive multiple sclerosis, but not in the primary progressive type …

… follows an initial relapsing-remitting multiple sclerosis phase typically lasting 10–… progressive
multiple sclerosis has an equal sex ratio, whereas secondary progressive multiple sclerosis …

PMS represents a significant challenge, as the pathogenesis of the disease is not well
understood, no validated outcome metrics have been established and clinical trial experience to …

Primary progressive multiple sclerosis (PPMS) is a rather unique form of the more common
relapsing inflammatory demyelinative disease. The absence of attacks that typify relapsing …