[HTML][HTML] Molecular glues modulate protein functions by inducing protein aggregation: A promising therapeutic strategy of small molecules for disease treatment
… representative cases of molecular glues and analyzes the binding mode of the molecular
glue–protein complex. Based on the aggregation mode of molecular glues mediating protein–…
glue–protein complex. Based on the aggregation mode of molecular glues mediating protein–…
PROTACs, molecular glues and bifunctionals from bench to bedside: Unlocking the clinical potential of catalytic drugs
… The vast majority of currently marketed drugs rely on small molecules with an ‘occupancy-driven’
mechanism of action (MOA). Therefore, the efficacy of these therapeutics depends on a …
mechanism of action (MOA). Therefore, the efficacy of these therapeutics depends on a …
Molecular glue degraders: exciting opportunities for novel drug discovery
T Lemaitre, M Cornu, F Schwalen, M Since… - Expert Opinion on …, 2024 - Taylor & Francis
… TPD offers a new method for investigating cellular pathways and shows potential as a
promising therapeutic strategy. Most TPD strategies are based on small-molecule degraders that …
promising therapeutic strategy. Most TPD strategies are based on small-molecule degraders that …
[HTML][HTML] Inhibitors, protacs and molecular glues as diverse therapeutic modalities to target cyclin-dependent kinase
… Recent studies also suggest that inhibiting CDK2 could be a promising therapeutic strategy
to treat acute myeloid leukemia (AML) [77,78]. Despite extensive efforts put forth by both …
to treat acute myeloid leukemia (AML) [77,78]. Despite extensive efforts put forth by both …
Molecular glues for targeted protein degradation: from serendipity to rational discovery
… (15) Recently, important progress has been made in the rational discovery or design of
molecular glue degraders, which is emerging as a promising strategy for therapeutic intervention (…
molecular glue degraders, which is emerging as a promising strategy for therapeutic intervention (…
Molecular glues: the adhesive connecting targeted protein degradation to the clinic
… these molecules, with a special focus on molecular glues. We also outline the advantages of
the molecular glues and … A selection of promising E3 ligase molecular glues, non-E3 ligase …
the molecular glues and … A selection of promising E3 ligase molecular glues, non-E3 ligase …
[HTML][HTML] Molecular glues and bifunctional compounds: Therapeutic modalities based on induced proximity
SL Schreiber - Cell Chemical Biology, 2024 - cell.com
… To get the most out of this promising therapeutic modality, it is useful to think of molecular
glues … dynamic properties are a promising class of emerging drugs that can also be considered …
glues … dynamic properties are a promising class of emerging drugs that can also be considered …
[HTML][HTML] Molecular glues: enhanced protein-protein interactions and cell proteome editing
EG Weagel, JM Foulks, A Siddiqui… - Medicinal Chemistry …, 2022 - Springer
… emerged as a promising therapeutic field for previously undruggable protein targets. Molecular
glues and … In this review, we discuss the function and rational design of molecular glues, …
glues and … In this review, we discuss the function and rational design of molecular glues, …
[HTML][HTML] Clues to molecular glues
TM Geiger, SC Schäfer, JK Dreizler, M Walz… - Current Research in …, 2022 - Elsevier
… Here we review the recently discovered molecular glues, general features and insights that
… molecular glues, and the implications for drug discovery directed towards molecular glues. …
… molecular glues, and the implications for drug discovery directed towards molecular glues. …
Development and therapeutic potential of GSPT1 molecular glue degraders: A medicinal chemistry perspective
X Chang, F Qu, C Li, J Zhang, Y Zhang… - Medicinal Research …, 2024 - Wiley Online Library
… In summary, compound 73 is an encouraging therapy for AML and is currently undergoing
preclinical development as a pioneering targeted protein degrader designed for CD33-…
preclinical development as a pioneering targeted protein degrader designed for CD33-…
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