Anticancer activity of a novel selective CYP17A1 inhibitor in preclinical models of castrate-resistant prostate cancer

PJ Toren, S Kim, S Pham, A Mangalji, H Adomat… - Molecular cancer …, 2015 - AACR
… the anticancer activity of VT-464 compared with abiraterone (ABI) in castrate-resistant prostate
cancer cell lines and xenograft models … The MR49F xenograft model was used to compare …

Flavopiridol (L86-8275): selective antitumor activity in vitro and activity in vivo for prostate carcinoma cells.

M Drees, WA Dengler, T Roth, H Labonte, J Mayo… - … Association for Cancer …, 1997 - AACR
tumor and five cell line-derived xenografts established by serial passage in nude mice in our
laboratory were used as tumor models for in … -stage sc growing prostate cancer xenografts. …

Antitumor activity of the histone deacetylase inhibitor MS‐275 in prostate cancer models

DZ Qian, YF Wei, X Wang, Y Kato, L Cheng… - The Prostate, 2007 - Wiley Online Library
… -sensitive and hormone refractory prostate cancer cell lines. Then, we tested the antitumor
activity of MS-275 in several prostate cancer models including subcutaneous and intratibia …

Protective immunosurveillance and therapeutic antitumor activity of γδ T cells demonstrated in a mouse model of prostate cancer

Z Liu, IEA Eltoum, B Guo, BH Beck… - The Journal of …, 2008 - journals.aai.org
… findings derived using the TRAMP model of mouse prostate cancer are presented in this …
for treating human prostate cancer, or other common human cancers of epithelial origin, …

Enigmol: A Novel Sphingolipid Analogue with Anticancer Activity against Cancer Cell Lines and In vivo Models for Intestinal and Prostate Cancer

H Symolon, A Bushnev, Q Peng, H Ramaraju… - Molecular cancer …, 2011 - AACR
… with suppression of colon cancer (20, 21), and then its efficacy was evaluated using mouse
models for colon and prostate cancer. Enigmol displayed anticancer activity in all these …

[HTML][HTML] Antitumor activity of alkylphospholipid edelfosine in prostate cancer models and endoplasmic reticulum targeting

ELH Dakir, C Gajate, F Mollinedo - Biomedicine & Pharmacotherapy, 2023 - Elsevier
… Here, we present evidence, by using different in vitro and in vivo prostate cancer models,
that edelfosine exerts a significant antitumor activity against prostate cancer, promoting …

… CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model

VD Handratta, TS Vasaitis, VCO Njar… - Journal of medicinal …, 2005 - ACS Publications
antitumor activity against a prostate cancer tumor to an extent that is superbly more effective
than castration. These impressive biological activities … treatment of prostate cancer in humans…

Synthesis, molecular modeling, in vivo study and anticancer activity against prostate cancer of (+)(S)-naproxen derivatives

K Birgül, Y Yıldırım, HY Karasulu, E Karasulu… - European journal of …, 2020 - Elsevier
… at the in vitro anticancer activity studies of the triazole-… prostate cancer cell line led to the in
vivo studies. In male nude mice in which prostate cancer was established with LNCaP cancer

Antitumor activity of NLG207 (formerly CRLX101) in combination with enzalutamide in preclinical prostate cancer models

KT Schmidt, CH Chau, JD Strope, ADR Huitema… - Molecular cancer …, 2021 - AACR
… had significant antitumor activity in two different preclinical prostate cancer models harboring
clinically … Antitumor activity of NLG207 and enzalutamide was demonstrated in both …

Antitumor activity of mifepristone in the human LNCaP, LNCaP‐C4, and LNCaP‐C4‐2 prostate cancer models in nude mice

MF El Etreby, Y Liang, MH Johnson, RW Lewis - The Prostate, 2000 - Wiley Online Library
… If the observed antitumor activity of mifepristone in our prostate cancer models is PR-mediated,
the prostate cancer tissue in our models should contain an adequate PR concentration. …