… induce protective autophagy through Nrf2-p62-keap1 feedback loop to sustain lung cancer
… this feedback loop in combination with ESI is a promising strategy for lung cancer therapy. …

… non-small-cell lung cancer (NSCLC) A549 cells … Lung cancer is the leading cause of cancer
death worldwide. Approximately 85% of lung cancer cases are non-small-cell lung cancer (…

… Herein, we demonstrated that autophagy was enhanced in osimertinib-resistant cells as well
as in lung cancer patients with resistance to osimertinib. We further showed that autophagy …

… SIRT1 to induce protective autophagy in NSCLC cells via inhibiting Akt/mTOR and activating
p38-MAPK pathway. Therefore, inhibition of protective autophagy may enhance anti-tumor …

… in 95D lung cancer cells. Furthermore, CuE induced protective autophagy mediated by ROS
… In the present study, the anticancer activities of CuE were examined using 95D lung cancer …

… autophagy has dual functions in cancer, in the present study we investigated the effects of
BITC on autophagy induction in human lung cancer … of 3 different human lung cancer cell lines …

… of nonprotective autophagy. Taken together, our current studies provide evidence that …
autophagy in p53wt non-small cell lung cancer cells can be “switched” to protective autophagy …

… in the treatment of lung cancer. In this study, we confirmed that DDP induced protective
autophagy in A549 cells, pharmacologic inhibition of autophagy using CQ suppressed cell …

… Many of the studies discussed in this review/commentary tend to support the more well-established
role of autophagy in mediating tumor cells survival and protection against noxious …

… autophagy with an autophagy inhibitor. All these results suggested that protective autophagy
… Further, we explored the mechanism of protective autophagy occurrence in NSCLC. Fu et al…