… protease into free amino acids and free and reutilizable … serves, most likely, as a recognition
marker for the 26S protease complex that degrades the protein moiety and releases free …

… Substrate recognition depends on a variety of factors, such as colocalization of protease
and substrate in the same cellular compartment and on substrate specificity. Substrate …

… mediated via the N-end rule pathway. The protein does not have a “destabilizing” N-terminal
residue and is probably recognized by UBRl via a “trans” mechanism (see below) that …

… a recognition marker for the 26S protease complex … recognized by the protease. However,
it is interesting to note that ubiquitination is not always essential for recognition by the protease…

… Although the mechanisms that underlie these complex … tin from Lys residues of end proteolytic
products, to disassemble … chains so that they will be recognized by the ubiquitin ‘‘receptor’’ …

… Most regulated proteolysis in eukaryotes occurs by a mechanism in which conjugation to
the conserved protein ubiquitin (Ub) targets substrates for degradation by 26S proteasomes (…

… Most of the vacuolar hydrolases are targeted to the vacuole via the secretory pathway. Upon
entry into the endoplasmic reticulum mediated by the signal recognition particle t51, signal …

… the ubiquitin system involves distinct recognition mechanisms which are specific for different …
proteolytic pathway? It appears to participate in covalent modification of selective proteolytic …

… as both “recognition” and “regulatory” signals that determine half-lives of normal proteins that
are degraded via the ATP-dependent, ubiquitin-dependent proteolytic pathway. An obvious …

… proteolysis, the energy invested in the synthesis of the peptide bond is released. Distinct
proteolytic mechanisms … In principle, recognition can be mediated via several mechanisms: …