… molecular glue libraries is not an easy task and requires extensive resources. We
previously developed platforms for rapid synthesis … of rapid synthesis of molecular glues (Rapid-Glue) …

… In this work, we developed a photoredox-catalyzed synthetic protocol for diverse C2-linked
molecules via a molecular glue strategy that employed gaseous acetylene under mild …

… These drawbacks raised the question of whether we could discover an alternate inhibitor
scaffold with greater potential for optimization through a de novo screen for molecular glues …

… the first fully synthetic FKBP12-mTOR molecular glues, which … Our results show that molecular
glues targeting flat surfaces … FKBP12 as a versatile presenter protein for molecular glues. …

… molecular glues to devise a classification system based on their mechanism of action. We find
that clinically approved molecular glues … the optimal molecular glue discovery method for a …

… allow for the transfer of the first ubiquitin molecule from the E2 enzyme to an accessible lysine
residue on the POI. This is followed by rapid transfer of additional ubiquitin units leading to …

… , we also show that these glues do not require pronounced … a conceptual framework for
rational molecular glue design. … efficient molecular glues, and that hydrophilicity of the gluing …

… cellular homeostasis and the balance between protein synthesis and protein degradation.
The concept of protein degradation is concerned with molecular glues, which form part of the …

… Using this protocol, we were able to rapidly synthesize a library of 132 compounds in 384-well
plates that could be used directly in biological assays. To inform and benchmark the use …

… On the other hand, the emerging strategy of molecular glue degraders offers a unique …
In this study, we synthesized a series of candidate compounds based on the molecule glue, …