… to rationally design molecular glues at that time. Thus, the development of molecular glues
… formation of ternary complexes, rational screening and design strategies for the discovery of …

… rational design principles for converting protein-targeting ligands into monovalent molecular
glue … as molecular glue and PROTAC design evolves, the definition between PROTACs and …

… applicability of molecular glue discovery. … of molecular glue-induced PPI complexes could
be helpful for virtual screening and the structure-based rational design of new molecular glues. …

… , we also show that these glues do not require pronounced … a conceptual framework for
rational molecular glue design. … efficient molecular glues, and that hydrophilicity of the gluing …

… On the other hand, the emerging strategy of molecular glue degraders offers a unique …
molecule glue, pomalidomide, using a “merger principle”, initially aiming to obtain molecular glue …

… Since most molecular glues are identified serendipitously, exploration of their systematic …
and rational design are important. In this review, representative examples of molecular glues …

… a more systematic and rational design approach [5h, … rational design tactics of molecular
glues will be discussed. The structure of the review will be organized around the molecular glue …

… molecular glues, which form part of the broader field of Targeted Protein Degradation (TPD).
Next, pharmacochemical strategies for the rational design of … -Based Drug Design (FBDD). …

… have already established these small-molecule degraders as a stand-… design. As such, we
anticipate that the field will produce the next generation of MGD drugs through rational design…

… In summary, the presented data provides a rational and scalable framework for the discovery
of cellularly active molecular glue degraders with established and nonobvious mechanisms …