Facilitating the development of molecular glues: opportunities from serendipity and rational design
W Jiang, Y Jiang, Y Luo, W Qiao, T Yang - European Journal of Medicinal …, 2023 - Elsevier
… to rationally design molecular glues at that time. Thus, the development of molecular glues
… formation of ternary complexes, rational screening and design strategies for the discovery of …
… formation of ternary complexes, rational screening and design strategies for the discovery of …
Rational chemical design of molecular glue degraders
ES Toriki, JW Papatzimas, K Nishikawa… - ACS central …, 2023 - ACS Publications
… rational design principles for converting protein-targeting ligands into monovalent molecular
glue … as molecular glue and PROTAC design evolves, the definition between PROTACs and …
glue … as molecular glue and PROTAC design evolves, the definition between PROTACs and …
Molecular glues for targeted protein degradation: from serendipity to rational discovery
… applicability of molecular glue discovery. … of molecular glue-induced PPI complexes could
be helpful for virtual screening and the structure-based rational design of new molecular glues. …
be helpful for virtual screening and the structure-based rational design of new molecular glues. …
Design principles for cyclin K molecular glue degraders
Z Kozicka, DJ Suchyta, V Focht, G Kempf… - Nature chemical …, 2024 - nature.com
… , we also show that these glues do not require pronounced … a conceptual framework for
rational molecular glue design. … efficient molecular glues, and that hydrophilicity of the gluing …
rational molecular glue design. … efficient molecular glues, and that hydrophilicity of the gluing …
Serendipitous discovery of Class I HDAC inhibitors from rational design of molecular glue degraders targeting HDAC
D Chen, S Lin, Z Zeng, J An, W Yan, Z Gu… - European Journal of …, 2024 - Elsevier
… On the other hand, the emerging strategy of molecular glue degraders offers a unique …
molecule glue, pomalidomide, using a “merger principle”, initially aiming to obtain molecular glue …
molecule glue, pomalidomide, using a “merger principle”, initially aiming to obtain molecular glue …
[HTML][HTML] Molecular glues modulate protein functions by inducing protein aggregation: A promising therapeutic strategy of small molecules for disease treatment
… Since most molecular glues are identified serendipitously, exploration of their systematic …
and rational design are important. In this review, representative examples of molecular glues …
and rational design are important. In this review, representative examples of molecular glues …
Rational Design of Molecular Glues: Breakthroughs and Perspectives
J An, X Zhang - 2023 - chemrxiv.org
… a more systematic and rational design approach [5h, … rational design tactics of molecular
glues will be discussed. The structure of the review will be organized around the molecular glue …
glues will be discussed. The structure of the review will be organized around the molecular glue …
Molecular glue degraders: exciting opportunities for novel drug discovery
T Lemaitre, M Cornu, F Schwalen, M Since… - Expert Opinion on …, 2024 - Taylor & Francis
… molecular glues, which form part of the broader field of Targeted Protein Degradation (TPD).
Next, pharmacochemical strategies for the rational design of … -Based Drug Design (FBDD). …
Next, pharmacochemical strategies for the rational design of … -Based Drug Design (FBDD). …
From thalidomide to rational molecular glue design for targeted protein degradation
… have already established these small-molecule degraders as a stand-… design. As such, we
anticipate that the field will produce the next generation of MGD drugs through rational design…
anticipate that the field will produce the next generation of MGD drugs through rational design…
Rational discovery of molecular glue degraders via scalable chemical profiling
C Mayor-Ruiz, S Bauer, M Brand, Z Kozicka… - Nature chemical …, 2020 - nature.com
… In summary, the presented data provides a rational and scalable framework for the discovery
of cellularly active molecular glue degraders with established and nonobvious mechanisms …
of cellularly active molecular glue degraders with established and nonobvious mechanisms …
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