… mouse models of sterile injury and explored the role of hyaluronan in mediating inflammation
following injury. The response of cultured monocytes to hyaluronan was different than the …

… Components of the extracellular matrix such as hyaluronan are … if hyaluronan fragments
released following injury can … Using genechip microarray analysis, a response to hyaluronan …

… be particularly relevant in settings of sterile inflammation. … as a form of pattern recognition
that distinguishes between tissue … regulation are integrated in injured and healing tissues. …

… DAMPs recognized by CD44 and P2X7 are hyaluronan and … The function of peritoneal
macrophages in sterile injury is … However, peritoneal macrophages recruited to sterile liver injury …

… , elements of the hyaluronan recognition process were … sterile intrinsic inflammatory process
is dependent on TLR4 activation, (b) sterile injury induces HA accumulation at the injured …

… together in the lung and are altered in response to injury. However from the reports
published thus far hyaluronan may offer a therapeutic benefit as a treatment in acute lung injury. …

… The association of increased HA deposition into the extracellular matrix (ECM) after tissue
injury and during inflammatory disease has been recognized for over 25 years. Increased …

… Hyaluronan fragments, for example, can signal through CD44, leading to MAPK activation
102 . Hyaluronan is also directly recognized by … of sterile bleomycin-induced lung injury 102 . …

… that these effects of hyaluronan administration were TLR4-… required for recognition of
hyaluronan released after sterile injury [ 62 ]… by LPS as compared with hyaluronan in cultured …

… The initiation of a sterile intrinsic inflammatory event induces HA accumulation at … injury has
been proposed to involve recognition of components of damaged cells by pattern recognition …