Mitochondrial transplantation attenuates neural damage and improves locomotor function after traumatic spinal cord injury in rats

MW Lin, SY Fang, JYC Hsu, CY Huang… - Frontiers in …, 2022 - frontiersin.org
Mitochondrial dysfunction is a hallmark of secondary neuroinflammatory responses and
neuronal death in spinal cord injury (SCI). Even though mitochondria-based therapy is an …

Effects of mitochondrial transplantation on bioenergetics, cellular incorporation, and functional recovery after spinal cord injury

JL Gollihue, SP Patel, KC Eldahan, DH Cox… - Journal of …, 2018 - liebertpub.com
Our previous studies reported that pharmacological maintenance of mitochondrial
bioenergetics after experimental spinal cord injury (SCI) provided functional …

[HTML][HTML] Transplantation of viable mitochondria attenuates neurologic injury after spinal cord ischemia

SY Fang, JN Roan, JS Lee, MH Chiu, MW Lin… - The Journal of Thoracic …, 2021 - Elsevier
Objectives Spinal cord ischemia (SCI) is one of the major concerns of postoperative
paraplegia during major vascular or aortic surgery. Since mitochondrial dysfunction …

Effects of brain-derived mitochondria on the function of neuron and vascular endothelial cell after traumatic brain injury

B Zhang, Y Gao, Q Li, D Sun, X Dong, X Li, W Xin… - World neurosurgery, 2020 - Elsevier
Objective Mitochondrial dysfunction plays an essential role in secondary brain injury
following traumatic brain injury (TBI). Interestingly, accumulating evidence has shown that …

Temporal characterization of mitochondrial bioenergetics after spinal cord injury

PG Sullivan, S Krishnamurthy, SP Patel… - Journal of …, 2007 - liebertpub.com
Mitochondrial dysfunction following spinal cord injury (SCI) may be critical for the
development of secondary pathophysiology and neuronal cell death. Previous studies have …

Mitochondrial dysfunction as a target in spinal cord injury: intimate correlation between pathological processes and therapeutic approaches

J Schmidt, HR Quintá - Neural regeneration research, 2023 - journals.lww.com
Traumatic spinal cord injuries interrupt the connection of all axonal projections with their
neuronal targets below and above the lesion site. This interruption results in either …

Mitochondrial function in spinal cord injury and regeneration

PG Slater, ME Domínguez-Romero, M Villarreal… - Cellular and Molecular …, 2022 - Springer
Many people around the world suffer from some form of paralysis caused by spinal cord
injury (SCI), which has an impact on quality and life expectancy. The spinal cord is part of …

[HTML][HTML] Targeted transplantation of engineered mitochondrial compound promotes functional recovery after spinal cord injury by enhancing macrophage …

J Xu, C Shi, F Yuan, Y Ding, Y Xie, Y Liu, F Zhu, H Lu… - Bioactive Materials, 2024 - Elsevier
Mitochondria are crucial in sustaining and orchestrating cellular functions. Capitalizing on
this, we explored mitochondrial transplantation as an innovative therapeutic strategy for …

[HTML][HTML] Targeting mitochondrial function for the treatment of acute spinal cord injury

ML McEwen, PG Sullivan, AG Rabchevsky… - …, 2011 - Elsevier
Traumatic injury to the mammalian spinal cord is a highly dynamic process characterized by
a complex pattern of pervasive and destructive biochemical and pathophysiological events …

The role of mitochondrial energy metabolism in neuroprotection and axonal regeneration after spinal cord injury

L Cheng, B Cai, D Lu, H Zeng - Mitochondrion, 2023 - Elsevier
Mitochondrial dysfunction occurs in the early stage of axonal degeneration after spinal cord
injury and involves oxidative stress, energy deficiency, imbalance of mitochondrial …