Glycosylation‐based serum biomarkers for cancer diagnostics and prognostics

A Kirwan, M Utratna, ME O'Dwyer… - BioMed research …, 2015 - Wiley Online Library
Cancer is the second most common cause of death in developed countries with
approximately 14 million newly diagnosed individuals and over 6 million cancer‐related …

The sweet and sour of serological glycoprotein tumor biomarker quantification

U Kuzmanov, H Kosanam, EP Diamandis - BMC medicine, 2013 - Springer
Aberrant and dysregulated protein glycosylation is a well-established event in the process of
oncogenesis and cancer progression. Years of study on the glycobiology of cancer have …

Glycans and glycoproteins as specific biomarkers for cancer

MJ Kailemia, D Park, CB Lebrilla - Analytical and bioanalytical chemistry, 2017 - Springer
Protein glycosylation and other post-translational modifications are involved in potentially all
aspects of human growth and development. Defective glycosylation has adverse effects on …

Glycomic approaches for the discovery of targets in gastrointestinal cancer

S Mereiter, M Balmaña, J Gomes, A Magalhães… - Frontiers in …, 2016 - frontiersin.org
Gastrointestinal (GI) cancer is the most common group of malignancies and many of its types
are among the most deadly. Various glycoconjugates have been used in clinical practice as …

A strategy for discovery of cancer glyco‐biomarkers in serum using newly developed technologies for glycoproteomics

H Narimatsu, H Sawaki, A Kuno, H Kaji, H Ito… - The FEBS …, 2010 - Wiley Online Library
Detection of cancer at early stages that can be treated through surgery is a difficult task. One
methodology for cancer biomarker discovery exploits the fact that glycoproteins produced by …

Glycoproteomics‐based identification of cancer biomarkers

EH Kim, DE Misek - International journal of proteomics, 2011 - Wiley Online Library
Protein glycosylation is one of the most common posttranslational modifications in
mammalian cells. It is involved in many biological pathways and molecular functions and is …

Developments in the identification of glycan biomarkers for the detection of cancer

LR Ruhaak, S Miyamoto, CB Lebrilla - Molecular & Cellular Proteomics, 2013 - ASBMB
Changes in glycosylation readily occur in cancer and other disease states. Thanks to recent
advances in the development of analytical techniques and instrumentation, especially in …

Glycosylation markers in cancer

A Silsirivanit - Advances in clinical chemistry, 2019 - Elsevier
Alteration of glycosylation, a hallmark of cancer, results in the production of tumor-
associated glycans or glycoproteins. These molecules are subsequently secreted or …

Evaluation of the serum N‐linked glycome for the diagnosis of cancer and chronic inflammation

JN Arnold, R Saldova, UMA Hamid, PM Rudd - Proteomics, 2008 - Wiley Online Library
The identification of serum biomarkers has lead to improvements in the detection and
diagnosis of cancer, and combinations of these biomarkers have increased further their …

Alterations in glycosylation as biomarkers for cancer detection

CA Reis, H Osorio, L Silva, C Gomes… - Journal of clinical …, 2010 - jcp.bmj.com
Glycoconjugates constitute a major class of biomolecules which include glycoproteins,
glycosphingolipids and proteoglycans. Glycans are involved in several physiological and …