Healthy aging has become a major goal of public health. Many studies have provided
evidence and theories to explain molecular mechanisms of the aging process. Recent …

Epigenetic regulation is facilitated by a battery of proteins that act as 'writers' or 'erasers' to
add or remove biochemical modifications to DNA and histone proteins. DNA modifications …

The field of epigenetics is the study of modifications of DNA and DNA-binding proteins that
alter the structure of chromatin without altering the nucleotide sequence of DNA; some of …

In the last decade we have eye-witnessed an explosion of information and interest by both
the scientists and general population about human genetic variability. The “dimension” of …

DNA methylation is a crucial epigenetic modification of the genome that is involved in
regulating many cellular processes. These include embryonic development, transcription …

The term epigenetics defines the heritable changes in gene expression that occur through
changes in the chromatin structure, rather than changes in the DNA sequence. The …

DNA and histones are packed together to contain heritable genetic information in the form of
chromatin, and while terminal tails generally protrude from the nucleosome core particles …

Chromatin modifications are established through the usage of chemical moieties attached to
DNA and histones. In particular two of those modifications, acetylation and methylation, are …

In mammals, cytosine in CpG sequences in genomic DNA is often methylated at the 5th
position. DNA methylation acts as a regulator of gene expression, and is crucial for …

Significance: Epidemiological and animal studies have demonstrated a close link between
maternal nutrition and chronic metabolic disease in children and adults. Compelling …