Human umbilical cord-derived mesenchymal stem cells-harvested mitochondrial transplantation improved motor function in TBI models through rescuing neuronal …

C Bamshad, MH Roudkenar, M Abedinzade… - International …, 2023 - Elsevier
Each year, traumatic brain injury (TBI) causes a high rate of mortality throughout the world
and those who survive have lasting disabilities. Given that the brain is a particularly dynamic …

Mesenchymal stem cells-derived mitochondria transplantation mitigates I/R-induced injury, abolishes I/R-induced apoptosis, and restores motor function in acute …

Z Pourmohammadi-Bejarpasi, AM Roushandeh… - Brain Research …, 2020 - Elsevier
Acute ischemia stroke (AIS) is one of the leading causes of mortality and disability
worldwide, and its neurological impacts are devastating and permanent. There is no efficient …

[HTML][HTML] Mitochondrial transfer from bone marrow mesenchymal stem cells to motor neurons in spinal cord injury rats via gap junction

H Li, C Wang, T He, T Zhao, Y Chen, Y Shen… - Theranostics, 2019 - ncbi.nlm.nih.gov
Recent studies have demonstrated that bone marrow mesenchymal stem cells (BMSCs)
protect the injured neurons of spinal cord injury (SCI) from apoptosis while the underlying …

Mitochondrial function in spinal cord injury and regeneration

PG Slater, ME Domínguez-Romero, M Villarreal… - Cellular and Molecular …, 2022 - Springer
Many people around the world suffer from some form of paralysis caused by spinal cord
injury (SCI), which has an impact on quality and life expectancy. The spinal cord is part of …

ROS-responsive exogenous functional mitochondria can rescue neural cells post-ischemic stroke

Y Li, Y Wang, W Yang, Z Wu, D Ma, J Sun… - Frontiers in Cell and …, 2023 - frontiersin.org
Background: The transfer of mitochondria from healthy mesenchymal stem cells (MSCs) to
injured MSCs has been shown to have potential therapeutic benefits for neural cell post …

Mesenchymal stem/stromal cell‐mediated mitochondrial transfer and the therapeutic potential in treatment of neurological diseases

D Han, X Zheng, X Wang, T Jin, L Cui… - Stem cells …, 2020 - Wiley Online Library
Mesenchymal stem/stromal cells (MSCs) are multipotent stem cells that can be derived from
various tissues. Due to their regenerative and immunomodulatory properties, MSCs have …

Current progress of mitochondrial transplantation that promotes neuronal regeneration

CY Chang, MZ Liang, L Chen - Translational neurodegeneration, 2019 - Springer
Background Mitochondria are the major source of intracellular adenosine triphosphate
(ATP) and play an essential role in a plethora of physiological functions, including the …

Mitochondria transplantation protects traumatic brain injury via promoting neuronal survival and astrocytic BDNF

J Zhao, D Qu, Z Xi, Y Huan, K Zhang, C Yu, D Yang… - Translational …, 2021 - Elsevier
Traumatic brain injury (TBI) is one of the leading causes of disability and paralysis around
the world. Secondary injury, characterized by progressive neuronal loss and astrogliosis …

Transfer of mitochondria from mesenchymal stem cells derived from induced pluripotent stem cells attenuates hypoxia-ischemia-induced mitochondrial dysfunction in …

Y Yang, G Ye, YL Zhang, HW He, BQ Yu… - Neural regeneration …, 2020 - journals.lww.com
Mitochondrial dysfunction in neurons has been implicated in hypoxia-ischemia-induced
brain injury. Although mesenchymal stem cell therapy has emerged as a novel treatment for …

Mitochondrial transplantation and immune response of human bone marrow mesenchymal stem cells for the Therapeutic of ischemic stroke

Y Liao, J Ming, W Song, G Chen, J Cui… - Current Stem Cell …, 2024 - ingentaconnect.com
Ischemic stroke is the leading cause of death and disability worldwide, with increasing
incidence and mortality, imposing a significant social and economic burden on patients and …