Balancing physicochemical properties of phenylthiazole compounds with antibacterial potency by modifying the lipophilic side chain
Bacterial resistance to antibiotics is presently one of the most pressing healthcare
challenges and necessitates the discovery of new antibacterials with unique chemical …
challenges and necessitates the discovery of new antibacterials with unique chemical …
Naphthylthiazoles: Targeting Multidrug-Resistant and Intracellular Staphylococcus aureus with Biofilm Disruption Activity
Thirty-two new naphthylthiazole derivatives were synthesized with the aim of exploring their
antimicrobial effect on multidrug-resistant Gram-positive bacteria. Compounds 25 and 32 …
antimicrobial effect on multidrug-resistant Gram-positive bacteria. Compounds 25 and 32 …
Modifying the lipophilic part of phenylthiazole antibiotics to control their drug-likeness
Compounds with high lipophilic properties are often associated with bad physicochemical
properties, triggering many off-targets, and less likely to pass clinical trials. Two …
properties, triggering many off-targets, and less likely to pass clinical trials. Two …
Development of Biphenylthiazoles Exhibiting Improved Pharmacokinetics and Potent Activity Against Intracellular Staphylococcus aureus
Exploring the structure–activity relationship (SAR) at the cationic part of arylthiazole
antibiotics revealed hydrazine as an active moiety. The main objective of the study is to …
antibiotics revealed hydrazine as an active moiety. The main objective of the study is to …
Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity
A new series of phenylthiazoles with t-butyl lipophilic component was synthesized and their
antibacterial activity against a panel of multidrug-resistant bacterial pathogens was …
antibacterial activity against a panel of multidrug-resistant bacterial pathogens was …
From phenylthiazoles to phenylpyrazoles: broadening the antibacterial spectrum toward carbapenem-resistant bacteria
The narrow antibacterial spectrum of phenylthiazole antibiotics was expanded by replacing
central thiazole with a pyrazole ring while maintaining its other pharmacophoric features …
central thiazole with a pyrazole ring while maintaining its other pharmacophoric features …
Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA)
MM Elsebaei, H Mohammad, M Abouf… - European journal of …, 2018 - Elsevier
The promising activity of phenylthiazoles against multidrug-resistant bacterial pathogens, in
particular MRSA, has been hampered by their limited systemic applicability, due to their …
particular MRSA, has been hampered by their limited systemic applicability, due to their …
Investigating the Antibacterial Activity of Biphenylthiazoles against Methicillin- and Vancomycin-Resistant Staphylococcus aureus (MRSA and VRSA)
M Hagras, H Mohammad, MS Mandour… - Journal of Medicinal …, 2017 - ACS Publications
Phenylthiazoles were reported previously as a new scaffold with antibacterial activity against
an array of multidrug-resistant staphylococci. However, their promising antibacterial activity …
an array of multidrug-resistant staphylococci. However, their promising antibacterial activity …
tert-Butylphenylthiazoles with an oxadiazole linker: a novel orally bioavailable class of antibiotics exhibiting antibiofilm activity
The structure–activity and structure–kinetic relationships of a new tert-butylphenylthiazole
series with oxadiazole linkers were conducted with the objective of obtaining a new orally …
series with oxadiazole linkers were conducted with the objective of obtaining a new orally …
Alkoxyphenylthiazoles with broad-spectrum activity against multidrug-resistant gram-positive bacterial pathogens
M ElAwamy, H Mohammad, A Hussien… - European Journal of …, 2018 - Elsevier
With the continued rise of antibiotic resistance and reduced susceptibility to almost all front-
line antibiotics, multidrug-resistant Gram-positive bacterial infections represent an incessant …
line antibiotics, multidrug-resistant Gram-positive bacterial infections represent an incessant …