A model for the transcriptional regulation of the CYP2B1/B2 gene in rat liver.
L Prabhu, P Upadhya, N Ram… - Proceedings of the …, 1995 - National Acad Sciences
The phenobarbitone-responsive minimal promoter has been shown to lie between nt-179
and nt+ 1 in the 5'(upstream) region of the CYP2B1/B2 gene in rat liver, on the basis of the …
and nt+ 1 in the 5'(upstream) region of the CYP2B1/B2 gene in rat liver, on the basis of the …
[HTML][HTML] Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes
P Honkakoski, R Moore, J Gynther, M Negishi - Journal of Biological …, 1996 - Elsevier
The mouse phenobarbital (PB)-inducible Cyp2b10 gene promoter has been isolated and
sequenced, and control of its expression has been characterized. The 1405-base pair (bp) …
sequenced, and control of its expression has been characterized. The 1405-base pair (bp) …
Involvement of Synthesis and Phosphorylation of Nuclear Protein Factors That Bind to the Positivecis-Acting Element in the Transcriptional Activation of the CYP2B1 …
CS Nirodi, S Sultana, N Ram, L Prabhu… - Archives of biochemistry …, 1996 - Elsevier
The synthesis and phosphorylation of protein factor (s) that bind to the positivecis-acting
element (− 69 to− 98 nt) of the CYP2B1/B2 gene have been examinedin vivoin the rat …
element (− 69 to− 98 nt) of the CYP2B1/B2 gene have been examinedin vivoin the rat …
Sequence of the rat PB-inducible CYP2B1 promoter
PM Shaw, M Edigkaufer, J Doehmer… - Biochimica et Biophysica …, 1996 - Elsevier
The 5′ flanking region of the rat PB-inducible CYP2B1 gene was isolated and the
sequence from+ 27 to− 3878 was determined. This sequence contains several putative …
sequence from+ 27 to− 3878 was determined. This sequence contains several putative …
Analysis of the promoter of the cytochrome P-450 2B2 gene in the rat
M Hoffmann, WH Mager, BJ Scholte, A Civil… - Gene …, 2018 - pmc.ncbi.nlm.nih.gov
About 3 kb of the promoter region of the gene encoding cytochrome P-450 2B2 (CYP2B2) in
the rat were sequenced and searched for potential cis-acting elements. Apart from putative …
the rat were sequenced and searched for potential cis-acting elements. Apart from putative …
Identification and functional characterization of a cis -acting positive DNA element regulating CYP 2B1/B2 gene transcription in rat liver
P Upadhya, MV Rao, V Venkateswar… - Nucleic acids …, 1992 - academic.oup.com
A positive cis-acting DNA element in the near 5'-upstream region of the CYP2B1/B2 genes
in rat liver was found to play an important role in the transcription of these genes. An …
in rat liver was found to play an important role in the transcription of these genes. An …
[HTML][HTML] Phenobarbital induction and tissue-specific expression of the rat CYP2B2 gene in transgenic mice.
R Ramsden, KM Sommer, CJ Omiecinski - Journal of Biological Chemistry, 1993 - Elsevier
To investigate molecular events regulating the transcription of genes inducible by
phenobarbital, transgenic mouse strains were developed incorporating rat cytochrome P450 …
phenobarbital, transgenic mouse strains were developed incorporating rat cytochrome P450 …
A 65-kDa protein mediates the positive role of heme in regulating the transcription of CYP2B1/B2 gene in rat liver
S Sultana, CS Nirodi, N Ram, L Prabhu… - Journal of Biological …, 1997 - ASBMB
Heme deficiency precipitated by CoCl 2 administration to rats leads to a striking decrease in
the inducibility of CYP2B1/B2 mRNA levels and its transcription by phenobarbitone (PB) …
the inducibility of CYP2B1/B2 mRNA levels and its transcription by phenobarbitone (PB) …
Transcriptional analysis in vivo of the hepatic genes, Cyp2b9 and Cyp2b10, by intravenous administration of plasmid DNA in mice
I Rivera-Rivera, J Kim, B Kemper - Biochimica et Biophysica Acta (BBA) …, 2003 - Elsevier
Phenobarbital (PB) responsiveness of CYP2B genes has been shown to be mediated by a
PB responsive unit (PBRU). The core of the PBRU contains two nuclear receptor sites, NR-1 …
PB responsive unit (PBRU). The core of the PBRU contains two nuclear receptor sites, NR-1 …
The CYP2B1 Proximal Promoter Contains a Functional C/EBP Regulatory Element
Y PARK, B KEMPER - DNA and cell biology, 1996 - liebertpub.com
ABSTRACT Cytochromes P450 2B1 and 2B2 (CYP2B1 and CYP2B2) are well-known
phenobarbital-inducible genes in rat liver. Potential transcriptional regulatory elements in …
phenobarbital-inducible genes in rat liver. Potential transcriptional regulatory elements in …