Synthesis de novo, acquisition by salvage and interconversion of purines and pyrimidines
represent the fundamental requirements for their eventual assembly into nucleic acids as …

Parasites are responsible for a wide variety of infectious diseases in human as well as in
domestic and wild animals, causing an enormous health and economical blight. Current …

Malaria is caused by protozoan parasites of the genus Plasmodium. Five species of
Plasmodium cause infection in humans, with the majority of lethal cases caused by …

Malaria still affects around 200 million people and is responsible for more than 400,000
deaths per year, mostly children in subequatorial areas. This disease is caused by parasites …

Malaria is a major cause of morbidity and mortality in humans. Artemisinins remain as the
first-line treatment for Plasmodium falciparum (P. falciparum) malaria although drug …

Malaria is a leading cause of morbidity and mortality in the tropics. Chemotherapeutic and
vector control strategies have been applied for more than a century but have not been …

For many years, the purine salvage pathway of parasitic protozoa has been regarded as an
attractive chemotherapeutic target. Parasitic protozoa lack de novo synthesis and rely …

Purine nucleoside phosphorylase (PNP) is an important component of the nucleotide
salvage pathway in apicomplexan parasites and a potential target for drug development …

Publisher Summary This chapter discusses the metabolism of purine and pyrimidine
nucleotides in parasitic protozoa and helminths. They are the monomeric units of both DNA …

Nucleotide metabolic pathways provide numerous successful targets for antiparasitic
chemotherapy, but the human pathogen Cryptosporidium parvum thus far has proved …