The adapter protein TRAF6 is critical for mediating signal transduction from members of the
IL-1R/TLR and TNFR superfamilies. The TRAF6 RING finger domain functions as an …

Tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) is a key mediator in
proximal signaling of the interleukin-1/Toll-like receptor and the TNF receptor superfamily …

TRAF2 is a RING finger protein that regulates the cellular response to stress and cytokines
by controlling JNK, p38 and NF‐κB signaling cascades. Here, we demonstrate that TRAF2 …

TRAF2 and TRAF5 are closely related members of the TRAF family of proteins. They are
important signal transducers for a wide range of TNF receptor superfamily members …

It is widely accepted that the essential role of TRAF6 in vivo is to generate the Lys63-linked
ubiquitin (K63-Ub) chains needed to activate the “master” protein kinase TAK1. Here, we …

TRAF proteins are intracellular signal transducers for a number of immune receptor
superfamilies. Specifically, TRAF2 interacts with members of the TNF receptor superfamily …

TAK1 mitogen‐activated protein kinase kinase kinase participates in the Interleukin‐1 (IL‐1)
signaling pathway by mediating activation of JNK, p38, and NF‐κB. TAK1‐binding protein 2 …

FRET experiments utilizing confocal microscopy or flow cytometry assessed homo-and
heterotrimeric association of human tumor necrosis factor receptor-associated factors …

Tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) is a key mediator in TNF
signaling. Previous studies suggested that TRAF2 functions as an adaptor in the NF-κB and …

Tumour necrosis factor (TNF) receptor associated factor (TRAF) family members share a
common domain architecture, but play non-redundant physiological roles in cell signalling …