Pharmacokinetic variability in drug levels represent for some drugs a major determinant of
treatment success, since sub-therapeutic concentrations might lead to toxic reactions …

Population pharmacokinetics has been an important technique used to explore and define
relevant sources of variation in drug exposure and response in patient populations. This has …

Individualized, model‐based, target‐oriented optimal concentration‐controlled dosing of HIV
medications can be beneficial to patients for whom there are limited dosing guidelines, such …

Objectives: The study objective was to derive reference pharmacokinetic curves of
antiretroviral drugs (ART) based on available population pharmacokinetic (Pop-PK) studies …

Pharmacokinetic studies rely on blood sampling at times relative to predefined dosing
intervals. Intensive sampling is often done under direct observation of dose taking, which …

Background Nevirapine-based antiretroviral therapy is widely used as a first-line treatment
for HIV-infected patients in resource-limited settings. Nevirapine plasma concentration has …

Abstract Background and Objectives: Therapeutic drug monitoring is applied to a range of
drugs. To predict an appropriate dosing regimen, models based on Bayesian techniques …

Population pharmacokinetic modelling is widely used within the field of clinical
pharmacology as it helps to define the sources and correlates of pharmacokinetic variability …

Aims Nevirapine is the first non-nucleoside reverse-transcriptase inhibitor approved and is
widely used in combination therapy to treat HIV-1 infection. The pharmacokinetics of …

Background: Population pharmacokinetic (PopPK) analyses often rely on steady state and
full adherence to prescribed dosage regimen assumptions from data gathered during …