Immune checkpoint therapy, which targets regulatory pathways in T cells to enhance
antitumor immune responses, has led to important clinical advances and provided a new …

Immune checkpoint receptors are crucial molecules for fine-tuning immune responses.
Checkpoint signaling dampens T cell activation to avoid autoimmunity and the destructive …

Immune responses are regulated by an exquisite system of checks and balances that
enable effective protective immunity and tolerance. A number of immunological checkpoints …

The release of negative regulators of immune activation (immune checkpoints) that limit
antitumor responses has resulted in unprecedented rates of long-lasting tumor responses in …

Immunotherapy has changed the landscape of cancer treatment. Checkpoint blockade
therapies unleash breaks in the immune system and induce long-lasting responses …

The immune system recognizes and is poised to eliminate cancer but is held in check by
inhibitory receptors and ligands. These immune checkpoint pathways, which normally …

The clinical success of immune checkpoint inhibitors has highlighted the central role of the
immune system in cancer control. Immune checkpoint inhibitors can reinvigorate anti-cancer …

Although T lymphocytes have long been appreciated for their role in the immunosurveillance
of cancer, it has been the realization that cancer cells may ultimately escape a response …

The success of checkpoint inhibitors has accelerated the clinical implementation of a vast
mosaic of single agents and combination immunotherapies. However, the lack of clinical …

Checkpoint blockade has formally demonstrated that reactivating anti-tumor immune
responses can regress tumors. However, this only occurs in a fraction of patients …