Gold nanoparticles functionalized with therapeutic and targeted peptides for cancer treatment

A Kumar, H Ma, X Zhang, K Huang, S Jin, J Liu, T Wei… - Biomaterials, 2012 - Elsevier
Functionalization of nanostructures such as gold nanoparticles (AuNPs) with different
biological molecules has many applications in biomedical imaging, clinical diagnosis and …

Gold nanoparticles surface-functionalized with paclitaxel drug and biotin receptor as theranostic agents for cancer therapy

DN Heo, DH Yang, HJ Moon, JB Lee, MS Bae, SC Lee… - Biomaterials, 2012 - Elsevier
We describe in this study whether the gold nanoparticle (AuNP) surface-functionalized with
PEG, biotin, paclitaxel (PTX) and rhodamine B linked beta-cyclodextrin (β-CD)(AuNP-5′) …

Peptide modified gold nanoparticles for improved cellular uptake, nuclear transport, and intracellular retention

C Yang, J Uertz, D Yohan, BD Chithrani - Nanoscale, 2014 - pubs.rsc.org
Gold nanoparticles (GNPs) are being extensively used in cancer therapeutic applications
due to their ability to act both as an anticancer drug carrier in chemotherapy and as a dose …

Functional gold nanoparticle− peptide complexes as cell-targeting agents

L Sun, D Liu, Z Wang - Langmuir, 2008 - ACS Publications
In this paper, we report a novel approach using peptide CALNN and its derivative
CALNNGGRRRRRRRR (CALNNR8) to functionalize gold nanoparticles for intracellular …

Peptide-functionalized gold nanoparticles: versatile biomaterials for diagnostic and therapeutic applications

J Zong, SL Cobb, NR Cameron - Biomaterials science, 2017 - pubs.rsc.org
Colloidal gold solutions have been used for centuries in a wide variety of applications
including staining glass and in the colouring of ceramics. More recently, gold nanoparticles …

Therapeutic nanomedicine based on dual-intelligent functionalized gold nanoparticles for cancer imaging and therapy in vivo

WH Chen, XD Xu, HZ Jia, Q Lei, GF Luo, SX Cheng… - Biomaterials, 2013 - Elsevier
A novel strategy to construct a therapeutic system based on functionalized AuNPs which can
specifically respond to tumor microenvironment was reported. In the therapeutic system …

Improving the brain delivery of gold nanoparticles by conjugation with an amphipathic peptide

S Guerrero, E Araya, JL Fiedler, JI Arias, C Adura… - …, 2010 - Taylor & Francis
Background & Aims: Gold nanoparticles (GNPs) have promising applications for drug
delivery as well as for the diagnosis and treatment of several pathologies, such as those …

Cancer-targeting multifunctionalized gold nanoparticles in imaging and therapy

PF Jiao, HY Zhou, LX Chen… - Current medicinal …, 2011 - ingentaconnect.com
Nanotechnology has provided many promising nanoplatforms for targeted cancer imaging
and therapy. Among these platforms, gold nanoparticles (GNPs) play a unique role in …

A reexamination of active and passive tumor targeting by using rod-shaped gold nanocrystals and covalently conjugated peptide ligands

X Huang, X Peng, Y Wang, Y Wang, DM Shin… - ACS …, 2010 - ACS Publications
The targeted delivery of nanoparticles to solid tumors is one of the most important and
challenging problems in cancer nanomedicine, but the detailed delivery mechanisms and …

Multifunctional PEI-entrapped gold nanoparticles enable efficient delivery of therapeutic siRNA into glioblastoma cells

L Kong, J Qiu, W Sun, J Yang, M Shen, L Wang… - Biomaterials …, 2017 - pubs.rsc.org
RNA interference (RNAi) has been considered as a promising strategy for effective treatment
of cancer. However, the easy degradation of small interfering RNA (siRNA) limits its …