How aging impacts vaccine efficacy: known molecular and cellular mechanisms and future directions
J Chen, JC Deng, DR Goldstein - Trends in molecular medicine, 2022 - cell.com
Aging leads to a gradual dysregulation of immune functions, one consequence of which is
reduced vaccine efficacy. In this review, we discuss several key contributing factors to the …
reduced vaccine efficacy. In this review, we discuss several key contributing factors to the …
Mechanisms underlying T cell immunosenescence: aging and cytomegalovirus infection
W Tu, S Rao - Frontiers in microbiology, 2016 - frontiersin.org
The ability of the human immune system to protect against infectious disease declines with
age and efficacy of vaccination reduces significantly in the elderly. Aging of the immune …
age and efficacy of vaccination reduces significantly in the elderly. Aging of the immune …
How can we improve vaccination response in old people? Part I: targeting immunosenescence of innate immunity cells
A Aiello, ME Ligotti, M Garnica, G Accardi… - International Journal of …, 2022 - mdpi.com
Vaccination, being able to prevent millions of cases of infectious diseases around the world
every year, is the most effective medical intervention ever introduced. However …
every year, is the most effective medical intervention ever introduced. However …
Immunosenescence: role and measurement in influenza vaccine response among the elderly
PV Targonski, RM Jacobson, GA Poland - Vaccine, 2007 - Elsevier
Immunosenescence refers to the inability of an aging immune system to produce an
appropriate and effective response to challenge. This immune dysfunction may manifest as …
appropriate and effective response to challenge. This immune dysfunction may manifest as …
Aging, sex, inflammation, frailty, and CMV and HIV infections
SX Leng, JB Margolick - Cellular immunology, 2020 - Elsevier
Aging is characterized by significant immune remodeling at both cellular and molecular
levels, also known as immunosenescence. Older adults often manifest a chronic low-grade …
levels, also known as immunosenescence. Older adults often manifest a chronic low-grade …
Reversing the immune ageing clock: lifestyle modifications and pharmacological interventions
NA Duggal - Biogerontology, 2018 - Springer
It is widely accepted that ageing is accompanied by remodelling of the immune system,
including reduced numbers of naïve T cells, increased senescent or exhausted T cells …
including reduced numbers of naïve T cells, increased senescent or exhausted T cells …
Immunosenescence and influenza vaccine efficacy
S Sambhara, JE McElhaney - Vaccines for Pandemic Influenza, 2009 - Springer
A number of protective immune functions decline with age along with physiological and
anatomical changes, contributing to the increased susceptibility of older adults to infectious …
anatomical changes, contributing to the increased susceptibility of older adults to infectious …
Immune system modulation in aging: Molecular mechanisms and therapeutic targets
B Cisneros, I García-Aguirre, J Unzueta… - Frontiers in …, 2022 - frontiersin.org
The function of the immune system declines during aging, compromising its response
against pathogens, a phenomenon termed as “immunosenescence.” Alterations of the …
against pathogens, a phenomenon termed as “immunosenescence.” Alterations of the …
Immunosenescence and vaccine failure in the elderly
B Grubeck-Loebenstein, S Della Bella, AM Iorio… - Aging clinical and …, 2009 - Springer
An age-related decline in immune responses in the elderly results in greater susceptibility to
infection and reduced responses to vaccination. This decline in immune function affects both …
infection and reduced responses to vaccination. This decline in immune function affects both …
Mechanisms of immunosenescence: lessons from models of accelerated immune aging
S Le Saux, CM Weyand… - Annals of the New York …, 2012 - Wiley Online Library
With increasing age, the ability of the adaptive immune system to respond to vaccines and to
protect from infection declines. In parallel, the production of inflammatory mediators …
protect from infection declines. In parallel, the production of inflammatory mediators …