Aging and impaired immunity to influenza viruses: implications for vaccine development
WM Liu, BAM van der Zeijst, CJP Boog… - Human …, 2011 - Taylor & Francis
Influenza infections are responsible for significant morbidity and mortality each year, with the
highest infection rates found in the elderly population. The main strategy to reduce the …
highest infection rates found in the elderly population. The main strategy to reduce the …
How inflammation blunts innate immunity in aging
The collective loss of immune protection during aging leads to poor vaccine responses and
an increased severity of infection for the elderly. Here, we review our current understanding …
an increased severity of infection for the elderly. Here, we review our current understanding …
Clinical relevance of age-related immune dysfunction
SC Castle - Clinical Infectious Diseases, 2000 - academic.oup.com
Immunosenescence is the state of dysregulated immune function that contributes to the
increased susceptibility to infection of the elderly. Extensive studies of inbred laboratory …
increased susceptibility to infection of the elderly. Extensive studies of inbred laboratory …
A systems biology approach to the effect of aging, immunosenescence and vaccine response
GA Poland, IG Ovsyannikova, RB Kennedy… - Current opinion in …, 2014 - Elsevier
Highlights•Immunosenescence leads to increased susceptibility to infection and decreased
vaccine response.•Heme-oxygenase gene expression may be an important element in age …
vaccine response.•Heme-oxygenase gene expression may be an important element in age …
[HTML][HTML] Ineffective humoral immunity in the elderly
KS McGlauchlen, LA Vogel - Microbes and infection, 2003 - Elsevier
As individuals age, dysfunction of the immune system leads to an increased incidence of
infectious disease. Due to the complex network of cellular interactions and the multi-factorial …
infectious disease. Due to the complex network of cellular interactions and the multi-factorial …
[HTML][HTML] T-cell immunity to influenza in older adults: a pathophysiological framework for development of more effective vaccines
One of the most profound public health consequences of immune senescence is reflected in
an increased susceptibility to influenza and other acute respiratory illnesses, as well as a …
an increased susceptibility to influenza and other acute respiratory illnesses, as well as a …
Translational research in immune senescence: assessing the relevance of current models
KP High, AN Akbar, J Nikolich-Zugich - Seminars in immunology, 2012 - Elsevier
Advancing age is accompanied by profound changes in immune function; some are induced
by the loss of critical niches that support development of naïve cells (eg thymic involution) …
by the loss of critical niches that support development of naïve cells (eg thymic involution) …
The immune system in the elderly: a fair fight against diseases?
The immune system is a very dynamic network, consisting of various innate and adaptive
cells acting via direct cell–cell contact, as well as indirect messaging mediated by soluble …
cells acting via direct cell–cell contact, as well as indirect messaging mediated by soluble …
Innate immunity in aging: impact on macrophage function
J Plowden, M Renshaw‐Hoelscher, C Engleman… - Aging cell, 2004 - Wiley Online Library
Innate and adaptive immune functions decline with age, leading to increased susceptibility
to infectious diseases and cancer, and reduced responses to preventive vaccination in the …
to infectious diseases and cancer, and reduced responses to preventive vaccination in the …
Biology of immune responses to vaccines in elderly persons
B Weinberger, D Herndler-Brandstetter… - Clinical Infectious …, 2008 - academic.oup.com
With increasing age, the human immune system undergoes characteristic changes, termed
immunosenescence, which lead to increased incidence and severity of infectious diseases …
immunosenescence, which lead to increased incidence and severity of infectious diseases …