Aging is accompanied by remodeling of the immune system. With time, this leads to a
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …

Like all somatic tissues, the human immune system changes with age. This is believed to
result in an increased frequency of, and susceptibility to, infectious disease and to contribute …

The relationship between advanced age and immunologic deficits is becoming an area of
rapidly advancing research. Many of the clinical hurdles in the elderly population result from …

Compromised immunity contributes to the decreased ability of the elderly to control
infectious disease and to their generally poor response to vaccination. It is controversial as …

Annual vaccination against seasonal influenza is recommended to decrease disease-
related mortality and morbidity. However, one population that responds suboptimally to …

Adaptive immunity undergoes severe deterioration with age and represents the main
problem in the elderly. However, evidence accumulated over the last decade supports the …

It is now becoming apparent that the immune system undergoes age‐associated alterations,
which accumulate to produce a progressive deterioration in the ability to respond to …

Aging results in systemic changes that leave older adults at much higher risk for adverse
outcomes following respiratory infections. Much work has been done over the years to …

Cellular senescence is characterized by irreversible cell cycle arrest in response to different
triggers and an inflammatory secretome. Although originally described in fibroblasts and cell …

Census reports of many countries indicate continuing trends for the graying of their
populations. For the United States alone, persons aged≥ 65 years are projected to …